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Takashima Lab
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A lab that uses naive human iPS cells, which are closer to a fertilized egg, to explore the beginnings of human life and regenerative medicine.
AboutAbout the lab
Controlling stem cells to support health.
Stem cells continually produce new cells in the body and replace aged ones, supporting us every day. The Takashima Lab aims to promote health by controlling stem cells.
The lab has succeeded in establishing naive human iPS cells, which are closer to a fertilized egg, and found that they can differentiate into cells of all lineages of the gestational period, including the placenta and yolk sac. It has also succeeded in creating stem cell-based embryo models that mimic human embryonic development.
Key terms
- Naive iPS cells
- iPS cells in a state closer to a fertilized egg than conventional iPS cells. They can also differentiate into the placenta and other tissues.
- Stem cell-based embryo model
- A three-dimensional model made from stem cells that mimics early human embryonic development.
- Yolk sac
- A sac that forms outside the embryo early in development, supplying nutrients to the embryo and producing blood cells.
- Tissue stem cells
- Stem cells found in each tissue of the body that replenish the cells of that tissue.
ResearchResearch themes
Building on cell culture technologies it developed in-house, the lab works on four topics: pluripotent stem cells, early human development, tissue stem cells, and non-human primates.
*Illustrative imageStudying early human development with stem cell-based embryo models
Using naive cells, which are close to a fertilized egg, the lab visualizes early development in vitro.
*Illustrative imageCreating next-generation iPS cells
Taking advantage of the properties of naive iPS cells, the lab works on producing iPS cells with greater differentiation capacity.
*Illustrative imageTissue stem cells and organ regeneration
The lab seeks to understand tissue stem cells and to restore function in aged or damaged tissues and organs. It is developing methods for regenerating organs using stem cells.
MembersFaculty
- ProfessorYasuhiro Takashima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Spectrum of pluripotency in the human embryo” Ávila-González D, Portillo W, García-López G, Molina-Hernández A, Díaz-Martínez NE and Díaz NF / CC BY 4.0 (cropped)
- Studying early human development with stem cell-based embryo models: “XBio illustration – Induced Pluripotent Stem Cells (iPSCs)” explorebiology / CC BY 4.0 (cropped)
- Creating next-generation iPS cells: “Induction of iPS cells” Y tambe / CC BY-SA 3.0 (cropped)
- Tissue stem cells and organ regeneration: “Regenerative-Medicine-Stem-Cells-Tissue-Engineering-Biomaterials” Umargani Jamal Mohamed / CC BY-SA 4.0 (cropped)
- Related lab (齊藤研究室): “Immobilization of Different Nucleic Acid Structures” Fozs / CC BY-SA 4.0 (cropped)
- Related lab (中川研究室): “Parkinson's induced pluripotent stem cell” US Department of Energy / Public domain (cropped)
- Related lab (下林研究室): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (高橋研究室): “Ribosome mRNA translation de” Matt / Public domain (cropped)
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