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Woltjen Lab
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The lab develops genome editing technologies that read, write, and regulate the human genome in iPS cells.
AboutAbout the lab
Reading, writing, and regulating the human genome.
The sequence of the human genome can now be read on a wide scale, but most of the functions encoded in it remain a mystery. Human iPS cells carry the same genome as the donor and can be differentiated into the cell types affected by disease, which makes them a powerful tool for studying genome function.
Woltjen Lab specializes in cutting-edge genome editing technologies in iPS cells. Through the three Rs, "Read," "wRite," and "Regulate," the lab aims for complete control of the human genome.
Many lab members are international researchers, creating an international and diverse research environment.
Key terms
- Genome editing
- Technology for cutting or rewriting DNA at targeted sites
- Reference genome
- A model genome sequence used as a standard for comparison
- Repetitive sequence
- A region of DNA in which similar sequences are repeated one after another
- Transposon
- A DNA fragment that can move within the genome. It is also used as a tool for delivering genes
ResearchResearch themes
The lab aims to understand the role of the genome in human health and to introduce new gene functions that enhance cell therapies.
*Illustrative imagePrecisely creating disease-causing mutations
The lab built its own reference genome for research-grade and clinical-grade iPS cells. It is now working to establish methods for precisely editing repetitive DNA sequences that may determine human traits.
*Illustrative imageGenome editing that reduces animal use
The lab reduced the variability of editing outcomes. It also showed that piggyBat, a transposon found in the bat genome, can efficiently produce genetically modified mice in a single generation.
MembersFaculty
- Associate ProfessorWOLTJEN Knut
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “XBio illustration – Genome Editing” explorebiology / CC BY 4.0 (cropped)
- Precisely creating disease-causing mutations: “MegaBACE DNA sequencing instrument” Nels A. Olson / CC BY-SA 4.0 (cropped)
- Genome editing that reduces animal use: “CRISPR-Cas9 Editing of the Genome ( )” National Human Genome Research Institute (NHGRI) / CC BY 2.0 (cropped)
- Related lab (下林研究室): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (川口研究室): “Islets of Langerhans (NIH BioArt 570)” NIH NIAID / CC BY 4.0 (cropped)
- Related lab (山本研究室): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Related lab (濵﨑研究室): “Thymus Lobule (NIH BioArt 576)” NIH NIAID / CC BY 4.0 (cropped)
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