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Takahashi Lab
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The lab investigates the mysteries of pluripotent stem cells through small proteins and functional RNAs.
AboutAbout the lab
Unraveling cell fate with molecules beyond the textbook.
Advances in technology are prompting a reexamination of the classical central dogma, in which RNA transcribed from DNA is translated into protein.
Takahashi Lab focuses on molecules that fall outside the classical central dogma, such as yet-undiscovered small proteins and functional RNAs.
With this new perspective, and using pluripotent stem cells as a model, the lab aims to uncover how cell fate is determined.
Key terms
- Central dogma
- The basic principle of life in which DNA information is transcribed into RNA and proteins are made from RNA
- Functional RNA
- RNA that is not made into protein and instead functions as RNA
- Translation
- The process of making proteins in the cell based on information in RNA
- Pluripotent stem cells
- Stem cells, such as iPS cells and ES cells, that can become almost all types of cells in the body
ResearchResearch themes
By focusing on protein translation, an area that remains little studied, the lab aims to reveal new forms of translational regulation and their significance, and thereby to address the mysteries of pluripotent stem cells and reprogramming.
*Illustrative imageTranslational control that supports pluripotency
Through genome-wide functional screening, the lab identified a group of genes essential for the self-renewal of pluripotent stem cells, and it is analyzing those among them that are involved in translation.
*Illustrative imageNon-canonical translation and small proteins
It has become clear that, beyond the canonical translation described in textbooks, there are various non-canonical translation mechanisms. The lab is investigating the cellular functions carried out by non-canonical translation and small proteins.
MembersFaculty
- Associate ProfessorKazutoshi Takahashi
- Assistant ProfessorChikako Okubo
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ribosome mRNA translation de” Matt / Public domain (cropped)
- Translational control that supports pluripotency: “Multiple Ribosomes Translation Protein Synthesis” Christinelmiller / CC BY-SA 4.0 (cropped)
- Non-canonical translation and small proteins: “Protein CTDSP1 PDB 1t9z” Emw / CC BY-SA 3.0 (cropped)
- Related lab (中川研究室): “Parkinson's induced pluripotent stem cell” US Department of Energy / Public domain (cropped)
- Related lab (下林研究室): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (山本研究室): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Related lab (齊藤研究室): “Immobilization of Different Nucleic Acid Structures” Fozs / CC BY-SA 4.0 (cropped)
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