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Yamamoto Lab
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A lab that explores how genomic information becomes cellular properties, through aging and cell fate conversion.
AboutAbout the lab
How genomic information becomes a cell's properties.
The Yamamoto Lab leverages iPS cell technology to pioneer new fields of life science at the molecular and cellular levels.
Focusing mainly on cell fate conversion, including the process by which iPS cells are induced, and on aging of the whole organism, the lab seeks to understand how information is retrieved from genomic DNA and linked to cell functions and properties.
It analyzes in an integrated way regulatory mechanisms spanning many levels, such as higher-order chromosome structure, epigenetic regulation, transcription, and translation.
Key terms
- Epigenetic
- A mechanism that determines whether genes are turned on or off without changing the DNA sequence.
- Cellular senescence
- A state in which cells stop dividing and change their properties due to stress and other factors.
- Spatial transcriptomics
- A method for examining which genes are active while preserving positional information within a tissue.
- Organoid
- A small organ-like tissue made by culturing stem cells and other cells in three dimensions.
ResearchResearch themes
The lab also works on gene expression analysis that preserves single-cell-level spatial information and the positions of RNA within cells.
*Illustrative imageCellular senescence in living organisms
By creating a new mouse model, the lab visualized and analyzed, at the single-cell level, the cells that senesce first and the secondary senescent cells that spread from them to their surroundings.
*Illustrative imagePredicting organoid differentiation from images
The lab built a machine learning model that predicts differentiation efficiency with high accuracy in organoids made from human iPS cells. Next, it will combine this with single-cell analysis and spatial transcriptomics.
MembersFaculty
- ProfessorTakuya Yamamoto
- Program-Specific Assistant Professor (Research Base)May Nakajima-Nakajima-Koyama
- Program-Specific Assistant ProfessorKazunori Sunadome
- Program-Specific Assistant Professor (Research Base)Ryusaku Matsumoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Cellular senescence in living organisms: “Factors inducing cellular senescence” Dong, Z / CC BY 4.0 (cropped)
- Predicting organoid differentiation from images: “Pancreatic Cancer Organoids” Olalekanusmanhas / CC BY 4.0 (cropped)
- Related lab (岩崎研究室): “General workflow for mass spectrometry based spatial proteomics” Yuen-ennu / CC BY-SA 4.0 (cropped)
- Related lab (高橋研究室): “Ribosome mRNA translation de” Matt / Public domain (cropped)
- Related lab (川口研究室): “Islets of Langerhans (NIH BioArt 570)” NIH NIAID / CC BY 4.0 (cropped)
- Related lab (下林研究室): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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