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Hamazaki Lab
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The lab investigates T cells, the command center of the immune system, and the thymus that produces them, and works to regenerate the thymus.
AboutAbout the lab
Understanding the thymus that makes T cells, and rebuilding it.
The immune system not only protects the body from infection, but is also deeply involved in the rejection of transplanted organs and in the onset of age-related diseases such as lifestyle-related diseases and cancer.
The Hamazaki Lab mainly studies T cells, which act as the command center of the immune system, and the thymus, the organ that produces them.
The lab aims to explore the basic principles of immunology and, building on them, develop new ways to control immunity, thereby contributing broadly to medicine and healthcare.
Key terms
- T cell
- A lymphocyte that acts as the command center of the immune system and attacks cancer cells and virus-infected cells
- Thymus
- An organ in the chest that produces and trains T cells; it shrinks after adolescence
- Thymic epithelial cell
- Supporting cells in the thymus that select and nurture T cells, for example by removing T cells that would attack the body itself
- Organoid
- A small organ-like tissue made by culturing stem cells or other cells in three dimensions
ResearchResearch themes
Centered on T cells and the thymus, the lab works on how the thymus forms and can be rebuilt, and on the relationship between T cell aging and disease.
Understanding how the thymus forms, and rebuilding it
Mainly in mice, the lab identified the progenitor cells and stem cells that give rise to thymic epithelial cells, and found that stem cell activity drops sharply before the thymus shrinks.
*Illustrative imageReproducing thymic function from iPS cells
The lab succeeded in generating mature thymic epithelial cells from human iPS cells in vitro. When organoids were formed together with human T cell progenitors, thymic function was shown to be reproducible in vitro.
*Illustrative imageT cell aging and age-related diseases
Using COVID-19 vaccination as an opportunity, the lab has clarified how human T cell responses differ from those in younger people. It is now working to elucidate the underlying mechanisms and develop ways to control them.
MembersFaculty
- ProfessorYoko Hamazaki
- Program-Specific Assistant ProfessorKohei Kometani
- Program-Specific Assistant Professor (Research Base)PRETEMER Yann
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Thymus Lobule (NIH BioArt 576)” NIH NIAID / CC BY 4.0 (cropped)
- Reproducing thymic function from iPS cells: “Organoid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- T cell aging and age-related diseases: “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Kawaguchi Lab): “Islets of Langerhans (NIH BioArt 570)” NIH NIAID / CC BY 4.0 (cropped)
- Related lab (Yamamoto Lab): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Related lab (Woltjen Lab): “XBio illustration – Genome Editing” explorebiology / CC BY 4.0 (cropped)
- Related lab (Shimobayashi Lab): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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