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Kawaguchi Lab
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The lab approaches the mechanisms of disease by studying pancreatic development, regeneration, aging, and cancer together.
AboutAbout the lab
Looking at development, regeneration, aging, and cancer at the same time.
iPS cells can be used to reproduce organ development in a culture dish to make cells for transplantation, and to reproduce disease mechanisms to aid drug development. However, for diseases involving many types of cells, it is difficult to reproduce the disease state with iPS cells alone, and model animals such as mice are also indispensable.
The Kawaguchi Lab studies endoderm-derived organs, including the pancreas, carrying out research using iPS cells and research on organ regeneration, aging, and cancer at the same time.
This is because organ development and the cell behavior seen in regeneration, aging, and cancer share common features, such as active proliferation and cell migration.
Key terms
- Endoderm
- One of the layers formed in early embryonic development; it gives rise to organs such as the pancreas, liver, and intestine
- Cellular senescence
- A state in which cells that have been exposed to stress stop dividing and lose function
- Chronic inflammation
- A state in which mild inflammation persists for a long time; it underlies aging and many diseases
- Tissue homeostasis
- The mechanism by which a tissue maintains a normal state while replacing its cells
ResearchResearch themes
The lab seeks to make the most of the advantages of studying organ development, regeneration, aging, and cancer at the same time.
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MembersFaculty
- ProfessorYoshiya Kawaguchi
- Program-Specific Lecturer (Research Base)Kenichiro Furuyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Islets of Langerhans (NIH BioArt 570)” NIH NIAID / CC BY 4.0 (cropped)
- A cellular stress response shared by pancreatic regeneration, aging, and cancer: “Rat pancreas cells” Katshutko / CC BY 4.0 (cropped)
- Related lab (Hamazaki Lab): “Thymus Lobule (NIH BioArt 576)” NIH NIAID / CC BY 4.0 (cropped)
- Related lab (Yamamoto Lab): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Related lab (Woltjen Lab): “XBio illustration – Genome Editing” explorebiology / CC BY 4.0 (cropped)
- Related lab (Iwasaki Lab): “General workflow for mass spectrometry based spatial proteomics” Yuen-ennu / CC BY-SA 4.0 (cropped)
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