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Iwasaki Lab
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The lab accurately measures protein levels to explore the mechanisms that create differences in cell function.
AboutAbout the lab
Measuring proteins, not RNA
Proteins are mainly what directly build and carry out the structure and function of cells, yet cell states have until now been discussed mostly on the basis of RNA levels. It is known that RNA abundance and protein abundance are not necessarily proportional.
The Iwasaki Lab develops proteome analysis technology with high accuracy and reproducibility, and uses it to uncover the principles that regulate protein abundance, translation, and degradation in pluripotent stem cells. A protein's location within the cell, its post-translational modifications, and how it forms complexes also determine the function of each cell type.
iPS cells, which have the same genome yet can differentiate into diverse cell types, are an ideal model for exploring the principles that regulate molecular abundance.
Key terms
- Proteome analysis
- Analysis that comprehensively identifies the proteins in a cell and measures their amounts
- Post-translational modification
- The addition of chemical marks to a protein after it has been made
- Pluripotent stem cells
- Stem cells, such as iPS cells and ES cells, that can become almost all types of cells in the body
- Mesoderm
- One of the layers formed in early development. It gives rise to blood, muscle, bone, and more
ResearchResearch themes
The lab works on the regulation of genes whose RNA and protein levels diverge greatly, the development of methods to identify and quantify proteins, and single-cell proteome analysis.
*Illustrative imageRevisiting the foundations of protein quantification
The lab systematically examined how sonication, a widely used method, affects protein identification and quantification, and showed that the recovery of certain groups of proteins can become biased.
*Illustrative imageAbnormal protein levels and disease
Studying Diamond-Blackfan anemia, the lab showed that the protein level of the causative gene changes substantially at the stage of differentiation into mesoderm, and that this correlates with reduced differentiation capacity.
MembersFaculty
- LecturerMio Iwasaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “General workflow for mass spectrometry based spatial proteomics” Yuen-ennu / CC BY-SA 4.0 (cropped)
- Revisiting the foundations of protein quantification: “Ultrasonic bath 1” Karelj / Public domain (cropped)
- Abnormal protein levels and disease: “Red blood cell” Database Center for Life Science (DBCLS) / CC BY 3.0 (cropped)
- Related lab (山本研究室): “Cellular senescence” Alshaebi F, Sciortino A / CC BY 4.0 (cropped)
- Related lab (中川研究室): “Parkinson's induced pluripotent stem cell” US Department of Energy / Public domain (cropped)
- Related lab (下林研究室): “Super Resolution Fluorescence Microscopy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (高橋研究室): “Ribosome mRNA translation de” Matt / Public domain (cropped)
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