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Mechanosensing Physiology Lab
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A lab that explores organ function and disease through PIEZO, the mechanism by which the body senses force.
AboutAbout the lab
Living tissues sense force in order to function
For organs such as the heart and lungs to function, it is important that mechanical factors such as volume and pressure change appropriately.
The Mechanosensing Physiology Lab (Nonomura Lab) focuses on PIEZO channels, which underlie mechanoreception (mechanosensing), the detection of such mechanical changes, and works to clarify the role of mechanosensing in organ function, development, and disease.
Key terms
- Mechanosensing
- The ability of cells to detect mechanical forces such as stretching and fluid flow
- PIEZO channels
- Ion channels in the cell membrane that open in response to mechanical force
- Sensory neurons
- Neurons that detect information from inside and outside the body and relay it to the brain and spinal cord
- Lymphatic vessels
- Vessels that carry excess fluid (lymph) in the body
ResearchResearch themes
The lab analyzes genetically modified PIEZO mice, as well as the responses of cultured cells, organoids, and tissues to mechanical stimulation.
*Illustrative imageMechanosensing in the lungs and breathing
The lab showed that sensory neurons expressing PIEZO2 extend into the lungs, where they sense lung inflation during inhalation and prevent overinflation.
*Illustrative imagePIEZO beyond sensory neurons
The lab showed that in lymphatic vessels, PIEZO1 is required to form the valves that prevent backflow of lymph. It also studies the roles of PIEZO and other mechanosensor molecules in the cells that form the brain.
MembersFaculty
- ProfessorKeiko Nonomura
- LecturerTeppei Goto
- Assistant ProfessorMinako Suzuki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Piezo1 homotrimer” KormiSK / CC BY-SA 4.0 (cropped)
- Mechanosensing in the lungs and breathing: “Alveoli (NIH BioArt 14)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- PIEZO beyond sensory neurons: “Piezo1” Rkott / CC BY-SA 4.0 (cropped)
- Related lab (Biomembrane Systems Lab): “CCR5 chemokine receptor (molecular surface representation) with an illustration of a cell membrane in the background” NIAID / CC BY 2.0 (cropped)
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