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Stem Cell Genetics Lab
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A lab that uses CRISPR to screen genes comprehensively and uncover the mechanisms of stem cells and cancer.
AboutAbout the lab
Genome editing for mammalian genetics
The Stem Cell Genetics Lab (Yusa Lab) has developed CRISPR screening methods based on the genome-editing technology CRISPR-Cas9 and uses them for genetics in mammalian cells.
The lab applies this technology to the biology of stem cells and cancer cells, aiming to contribute to regenerative medicine and cancer therapy through insights from basic biology.
Key terms
- CRISPR-Cas9
- A leading genome-editing tool that can cut DNA at a targeted location
- Forward genetics
- A research approach that comprehensively identifies the genes involved in a given trait without starting from a hypothesis
- Pluripotent stem cells
- Stem cells, such as ES cells and iPS cells, that can become almost any type of cell in the body
ResearchResearch themes
Using CRISPR screening, which applies CRISPR-Cas9 to forward genetics, the lab efficiently identifies genes involved in a wide range of biological phenomena. It focuses in particular on the regulation of transcription in the nucleus.
*Illustrative imageHow stem cells maintain the undifferentiated state and differentiate
Using CRISPR screening, the lab identifies genes involved in how human pluripotent stem cells maintain their undifferentiated state and how cells differentiate, and analyzes how these genes function.
*Illustrative imageCancer cell growth and drug response
Using CRISPR screening, the lab identifies genes involved in cancer cell dependencies and the effectiveness of anticancer drugs, aiming to lead to new therapies and the development of combination drugs.
MembersFaculty
- ProfessorKosuke Yusa
- Assistant ProfessorYusuke Tarumoto
- Assistant ProfessorGohei Nishibuchi
- Assistant ProfessorKazunari Aoki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cas9 5AXW plain” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- How stem cells maintain the undifferentiated state and differentiate: “Иммуноцитохимическое окрашивание культуры клеток человека” Daria Goliusova / CC BY 4.0 (cropped)
- Cancer cell growth and drug response: “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (Life Data Science Lab): “Single Cell RNA Seq (NIH BioArt 767)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Biomembrane Systems Lab): “CCR5 chemokine receptor (molecular surface representation) with an illustration of a cell membrane in the background” NIAID / CC BY 2.0 (cropped)
- Related lab (Mechanosensing Physiology Lab): “Piezo1 homotrimer” KormiSK / CC BY-SA 4.0 (cropped)
- Related lab (Developmental Epigenome Lab): “0300 Flourescence Stained new” OpenStax / CC BY 4.0 (cropped)
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