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Ultrastructural Virology Lab
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The lab uses electron microscopy to observe viruses, investigate how they replicate, and work toward controlling them.
AboutAbout the lab
Seeing, understanding, and stopping virus replication.
The Ultrastructural Virology Lab (Noda Lab) focuses on viruses that cause disease in humans, such as influenza virus, Ebola virus, and Lassa virus, and aims to elucidate how they replicate inside cells and how they cause disease.
The lab specializes in visual analysis using various electron microscopy methods, including cryo-electron microscopy, and can reveal the structures of virus particles and infected cells at a range of resolutions.
The lab also incorporates techniques from other fields, such as structural biology and developmental biology.
Key terms
- Cryo-electron microscopy
- A technique that rapidly freezes a specimen and images it with an electron microscope to determine the three-dimensional structure of molecules and particles
- Nucleocapsid
- A complex of viral genomic RNA and proteins bound together
- Reverse genetics
- A method of artificially assembling genes to generate a virus and study its function
- Organoid
- A small, organ-like tissue made by culturing stem cells and other cells in three dimensions
ResearchResearch themes
Based on the scientific evidence obtained through basic research, the lab also aims to develop new therapies.
*Illustrative imageHow Influenza Virus Passes Down Its Genome
The genomic RNA of influenza virus is divided into eight segments. By combining reverse genetics with electron microscopy, the lab showed that the eight genome segments are arranged in an orderly pattern and selectively incorporated into progeny virus particles.
*Illustrative imageThe Nucleocapsid of Ebola Virus
The Ebola virus nucleocapsid is a huge helical complex responsible for genome transcription and replication, among other functions. Using cryo-electron microscopy, the lab determined its core structure at high resolution.
*Illustrative imageStudying Infection with Human Respiratory Organoids
The lab generates human respiratory epithelial organoids from ES cells and iPS cells to study virus replication and infection responses as they occur in the body.
MembersFaculty
- ProfessorTakeshi Noda
- Assistant ProfessorYukiko Muramoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
- How Influenza Virus Passes Down Its Genome: “Influenza A Virus (H1N1)-1” NIH Image Gallery / Public domain (cropped)
- The Nucleocapsid of Ebola Virus: “Ebola virus virion” CDC/Cynthia Goldsmith / Public domain (cropped)
- Studying Infection with Human Respiratory Organoids: “SI organoid 1” Abhimanu.pandey / CC BY 4.0 (cropped)
- Related lab (ウイルス分子病態分野): “Herpesvirus (negative staining)” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (RNAウイルス分野): “Novel Coronavirus SARS-CoV- )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (がんウイルス分野): “HumanPapillomavirus” NIAID / Public domain (cropped)
- Related lab (細胞制御分野): “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
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