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Clinical Research and Development Lab
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A lab that investigates how malignant lymphoma arises and what can become a therapeutic target.
AboutAbout the lab
Unexpected therapeutic targets in malignant lymphoma.
Malignant lymphoma is one of the representative malignant tumors, and its incidence is rising in Japan as well.
The Clinical Research and Development Lab focuses on the relationship between malignant lymphoma and the surrounding non-tumor cells. It works to elucidate the molecular pathogenesis, identify the sites of action of existing drugs, and develop new treatments.
Because the tumor cells themselves are immune cells, understanding the molecular pathogenesis can sometimes reveal therapeutic targets in unexpected places.
The research is conducted jointly with the Department of Hematology.
Key terms
- Malignant lymphoma
- A disease in which lymphocytes, a type of white blood cell, become cancerous
- Tumor microenvironment
- The environment around cancer cells, made up of cells such as immune cells and blood vessels, and other substances
- Epigenome
- A system of chemical marks that determines which genes are active without changing the DNA sequence
- Notch signaling
- One of the mechanisms by which cells in contact with each other pass on information and determine cell differentiation and function
ResearchResearch themes
The lab reproduces the interactions among lymphoma cells using lymphoma cell lines and mouse models, and aims to develop treatments that focus on the roles of genetic abnormalities and on the relationship with the tumor microenvironment.
*Illustrative imageThe Epigenome of Malignant Lymphoma
In follicular lymphoma, genetic abnormalities in molecules involved in epigenomic modification are found at a high frequency. The lab studies the significance of abnormal epigenomic modification and the mechanisms of action of drugs that act on the epigenome.
*Illustrative imageAltering Signaling Through Ubiquitin Modification
The survival and proliferation of B-cell lymphoma involve intracellular signaling that is influenced by the immune microenvironment. The lab focuses on drugs that target the ubiquitin modification machinery and conducts joint research with a company.
*Illustrative imageStructural Abnormalities of the Genome
The lab analyzes next-generation sequencing data with a new algorithm that evaluates genomic structural abnormalities such as deletions, insertions, duplications, inversions, and translocations, and explores their significance in malignant lymphoma.
*Illustrative imageB Cells and Notch Signaling
The lab creates model mice in which Notch signaling is specifically activated in mature B cells, and investigates the progression of B-cell lymphoma and the mechanisms that suppress T-cell antitumor immunity.
MembersFaculty
- ProfessorMomoko Nishikori
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Follicular lymphoma -- low mag” Nephron / CC BY-SA 3.0 (cropped)
- The Epigenome of Malignant Lymphoma: “Chromosome-DNA-gene” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Altering Signaling Through Ubiquitin Modification: “Ubiquitin cartoon” en:User:Rogerdodd / Public domain (cropped)
- Structural Abnormalities of the Genome: “Chromosome Terminology” Christinelmiller / CC BY-SA 4.0 (cropped)
- B Cells and Notch Signaling: “Notch lateral effects” Laura A. Tiemeijer / CC BY 4.0 (cropped)
- Related lab (Clinical Genome Analysis Lab): “Minimally differentiated acute myeloid leukemia (AML-M0)” Animalculist / CC BY-SA 4.0 (cropped)
- Related lab (Advanced Medical Instrumentation Systems Lab): “Nihonmedaka” NOZO / CC BY 3.0 (cropped)
- Related lab (Developmental Neurobiology Lab): “The developing cerebral cortex” Shyam K Akula , David Exposito-Alonso , Christopher A Walsh / CC BY 4.0 (cropped)
- Related lab (Glycobiology Lab): “Glycan” Guennadi Kozlov, Kalle Gehring / CC BY-SA 4.0 (cropped)
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