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Clinical Genome Analysis Lab
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A lab that identifies genomic abnormalities in leukemia and develops new tests and treatments.
AboutAbout the lab
To raise the cure rate of blood cancers.
The Clinical Genome Analysis Lab (Matsuo Lab) aims to improve treatment outcomes for hematologic malignancies. It analyzes the genomic abnormalities involved in onset, progression, and response to treatment, and works to elucidate the molecular pathogenesis.
Based on these findings, the lab is developing new tests useful for diagnosis and prognosis prediction, as well as new treatments.
Students, mainly those with a background in clinical laboratory science, learn genome analysis and molecular biology methods hands-on.
The lab conducts joint research with Kyoto University Hospital and with medical institutions across Japan that participate in the Japan Children's Cancer Group.
Key terms
- Acute myeloid leukemia
- A leukemia in which cells in the bone marrow, where blood is made, become cancerous and multiply rapidly. Also abbreviated AML
- Genomic abnormality
- Mutations and rearrangements occurring in the genome, the entirety of an organism's genetic information
- Prognosis
- The expected future course of a disease and the likelihood of recovery
- Extramedullary infiltration
- The spread and growth of leukemia cells in places outside the bone marrow, such as the skin and organs
ResearchResearch themes
Focusing mainly on acute myeloid leukemia (AML), the lab finds genomic abnormalities by next-generation sequencing and develops new tests and treatments based on them.
*Illustrative imageIdentifying Genomic Abnormalities in AML and Their Functions
The lab identifies genomic abnormalities involved in the onset and progression of AML, and analyzes their functions using AML cells and mice.
*Illustrative imageSearching for Differentiation-Inducing Drugs
The lab uses screening to search for therapeutic drugs that make AML cells differentiate into mature cells.
*Illustrative imagePredicting Extramedullary Infiltration
The lab looks for markers that predict whether extramedullary infiltration of AML will occur, and is working to establish a mouse model.
*Illustrative imageWhole-Genome Analysis from Small Samples
The lab is developing methods that make it possible to analyze the whole genome even from small clinical samples.
MembersFaculty
- Associate ProfessorHidemasa Matsuo
VoicesStudent voices
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Report an errorAbout the images
For images provided to us or used with permission, the source is listed on each line. Wikimedia Commons images are illustrative and were not taken at the lab (they are cropped). Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Minimally differentiated acute myeloid leukemia (AML-M0)” Animalculist / CC BY-SA 4.0 (cropped)
- Identifying Genomic Abnormalities in AML and Their Functions: “Acute Myeloid Leukemia (M2 type)” Makysm / CC0 (cropped)
- Searching for Differentiation-Inducing Drugs: “Acute Myeloid Leukaemia (AML)” Prof Osaro Erhabor / CC BY-SA 4.0 (cropped)
- Predicting Extramedullary Infiltration: “Relative incidence of acute myeloid leukemia subtypes” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D. / CC0 (cropped)
- Whole-Genome Analysis from Small Samples: “DNA Sequencing Method ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Home Healthcare and Dementia Lab (formerly Home Healthcare Nursing Lab)): “Droitwich Mews, Residential, Respite and Dementia Care - geograph.org.uk - 6713023” Jeff Gogarty / CC BY-SA 2.0 (cropped)
- Related lab (Neurorehabilitation Lab): “Neurorehabilitation Class” ニューロリハビリテーション研究室 / 研究室からの
提供 (cropped) - Related lab (Clinical Research and Development Lab): “Follicular lymphoma -- low mag” Nephron / CC BY-SA 3.0 (cropped)
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