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Developmental Neurobiology Lab
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The lab uses mice to explore how neural circuits in the brain are built.
AboutAbout the lab
How are neural circuits in the brain built?
The Developmental Neurobiology Lab (Nakagawa Lab) conducts research aimed at elucidating the molecular and cellular mechanisms that regulate the formation of neural circuits in the cerebral cortex.
The lab focuses on two processes: how the tissue architecture of the cerebral cortex is established during the fetal period, and how circuits are remodeled in response to neural activity during postnatal development.
By visualizing and manipulating changes that occur inside neural stem cells and neurons, the lab aims to understand the complex mechanisms of neural circuit formation.
Key terms
- Cerebral cortex
- The layer covering the surface of the brain. It carries out higher functions such as thinking, judgment, and memory.
- Neural stem cell
- A cell that divides and gives rise to neurons and other cell types.
- Organelle
- A small structure within a cell that performs a specific function.
- Neurodevelopmental disorder
- A condition in which characteristic traits appear from childhood due to differences in the course of brain development.
ResearchResearch themes
Using mice as a model animal, the lab studies the molecular and cellular mechanisms that regulate the development of the cerebral cortex.
*Illustrative imageCerebral cortex development viewed through intracellular machinery
The lab focuses on the roles of intracellular machinery such as adhesion molecule complexes, intracellular signaling pathways, microtubules, and organelles, and develops tools to visualize and manipulate them in vivo.
*Illustrative imageCellular pathology of neurodevelopmental disorders
Using disease model mice, the lab analyzes how the breakdown of the mechanisms of cerebral cortex development is related to the cellular pathology seen in neurodevelopmental disorders.
MembersFaculty
- Associate ProfessorNaoki Nakagawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “The developing cerebral cortex” Shyam K Akula , David Exposito-Alonso , Christopher A Walsh / CC BY 4.0 (cropped)
- Cerebral cortex development viewed through intracellular machinery: “RUH PMH” Break-point / CC BY-SA 4.0 (cropped)
- Cellular pathology of neurodevelopmental disorders: “Pyramidal neurons, human fetus 8 months (K. Brodmann, 1909, p. 27, Fig. 5)” Korbinian Brodmann / Public domain (cropped)
- Related lab (Biological Function Lab): “Synaptic vesicle model” Qualiesin / CC BY-SA 4.0 (cropped)
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- Related lab (Morphogenesis and Basic Medical Science (Pathology) Lab): “Development of the notochord in a stage 8 (17–19 days) human embryo” de Bree K, de Bakker BS, Oostra R-J / CC BY 4.0 (cropped)
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