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Glycobiology Lab
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The lab studies how glycans give cells their individuality and develops technologies to freely control their structures.
AboutAbout the lab
Each glycan carries information about life.
Glycans modify the functions of proteins and lipids and give each cell its individuality.
The Glycobiology Lab (Morise Lab) focuses on specific glycans to uncover their roles, while also developing technologies to control the expression of diverse glycan structures.
If students find an interesting glycan-related topic, the lab also provides an environment where research can move forward with student-led ideas.
The lab collaborates with the Nonaka Lab and Nakagawa Lab in the same field.
Key terms
- Glycan
- A chain made of many sugars linked together. It changes how proteins and lipids function.
- Biomarker
- A substance in the body that provides clues about whether a disease is present or how far it has progressed.
- Golgi apparatus
- An organelle in the cell that finishes proteins, for example by attaching glycans to them.
- Nanobody
- A very small antibody made up of only part of an antibody heavy chain (a heavy-chain single-domain antibody).
ResearchResearch themes
The lab's research centers on analyzing a characteristic glycan found in the kidney and pioneering techniques to attach glycans with the structures researchers want.
*Illustrative imageGlycans that protect the kidney
The non-sulfated HNK-1 glycan consists of three characteristic sugars and is strongly expressed in the kidney. Because this glycan has been found to act to protect kidney function, the lab is investigating its molecular mechanism.
*Illustrative imageTechnology for attaching glycans as desired
Immature glycans on proteins mature in the Golgi apparatus and take on diverse structures. The lab has found that by linking a nanobody to a specific glycosyltransferase, it may be possible to attach a desired glycan to a targeted molecule.
MembersFaculty
- Associate ProfessorJyoji Morise
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Glycan” Guennadi Kozlov, Kalle Gehring / CC BY-SA 4.0 (cropped)
- Glycans that protect the kidney: “Kidney Nephron es” Modificado de Kidney Nephron.png en Wikimedia Commons realizado por Holly Fischer / CC BY-SA 3.0 (cropped)
- Technology for attaching glycans as desired: “Golgi apparatus 1 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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