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Molecular Life and Basic Medical Science (Molecular Pathology) Lab
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A lab that finds disease-related molecules among vast numbers of peptides and creates new diagnostics and treatments.
AboutAbout the lab
Meeting diversity with diversity
Molecules that make up living organisms, such as nucleic acids, proteins, and glycans, are diverse in both structure and function.
The Nonaka Lab, within Molecular Life and Basic Medical Science, aims to develop methods that use phage libraries containing vast numbers of peptide sequences to efficiently pick out important molecules from among diverse molecules and control their functions.
By combining phage display with next-generation sequencing, the lab is building a system to comprehensively obtain peptide sequences that bind to target molecules.
Third-year undergraduate students are also assigned to the lab.
Key terms
- Phage display
- A method in which various peptides are displayed on the surface of viruses that infect bacteria (phages), and those that bind to a target molecule are selected
- Peptide
- A molecule made of a few to a few dozen amino acids linked together; smaller than a protein
- Glycan
- A chain of many sugars linked together. Found on cell surfaces and elsewhere, and involved in processes such as cell-to-cell recognition
- Epitope
- A small marker region within a molecule to which an antibody binds
ResearchResearch themes
Centered on phage display, the lab develops new diagnostics and treatments for intractable diseases such as cancer, allergies, and autoimmune diseases.
*Illustrative imageDelivering Drugs to Tumors with Glycan-Mimicking Peptides
The lab has shown that peptides mimicking glycan structures reach and accumulate even in brain tumors. It is now studying in detail the mechanism by which the peptides gather in malignant tumors.
*Illustrative imageBiopharmaceuticals the Body Rarely Makes Antibodies Against
The lab conducts basic research aimed at developing biopharmaceuticals against which antibodies are less likely to form, in collaboration with the Graduate School of Pharmaceutical Sciences and organic chemistry labs at other universities.
*Illustrative imageNew Diagnostics for Allergies and Autoimmune Diseases
The lab focuses on epitopes, the structural units to which autoantibodies bind. It conducts research on methods to efficiently identify antigen proteins from epitope sequences, and on comprehensively obtaining the sequences of peptides that mimic epitopes.
MembersFaculty
- ProfessorMotohiro Nonaka
- Assistant ProfessorKatsuaki Higashi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Linear epitope and Conformational epitope” Roohparvar.me / CC BY 4.0 (cropped)
- Delivering Drugs to Tumors with Glycan-Mimicking Peptides: “알텀 펩타이드 전달 시스템” Srbiotek / CC BY-SA 4.0 (cropped)
- Biopharmaceuticals the Body Rarely Makes Antibodies Against: “Epitope-mapping illustration-6-copy” Kathryn Edmondson (as employee of Integral Molecular) / CC BY-SA 4.0 (cropped)
- New Diagnostics for Allergies and Autoimmune Diseases: “The specificity of epitope-antibody binding” Roohparvar.me / CC BY 4.0 (cropped)
- Related lab (Developmental Neurobiology Lab): “The developing cerebral cortex” Shyam K Akula , David Exposito-Alonso , Christopher A Walsh / CC BY 4.0 (cropped)
- Related lab (Glycobiology Lab): “Glycan” Guennadi Kozlov, Kalle Gehring / CC BY-SA 4.0 (cropped)
- Related lab (Lifestyle-Related Disease Nursing Lab): “Capteur de glycémie pour personnes diabétiques” Celeda / CC BY-SA 4.0 (cropped)
- Related lab (Biomedical Data Science Lab): “Principles of machine learning” Langs, G., Röhrich, S., Hofmanninger, J. et al. / CC BY 4.0 (cropped)
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