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Cellular Oncology Lab
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The lab studies NK cell-mediated cancer immunity at the molecular level in order to develop new therapies.
AboutAbout the lab
Using NK cells to aim for a complete cure for cancer.
The Division of Tumor Immune Responses is a lab that studies how immune cells recognize and attack cancer cells (cancer immunity).
The lab focuses on cancer immunity mediated by immune cells called NK cells.
The lab conducts basic research that examines, at the molecular level, the entire process from when an NK cell encounters a cancer cell to when it attacks and kills it, as well as research to develop immunotherapies that use NK cells.
The lab is located at Aichi Cancer Center (Chikusa Ward, Nagoya), and graduate students from Nagoya University's collaborative graduate program are also enrolled.
Key terms
- NK cells
- A type of immune cell that recognizes and attacks cancer cells. They can also attack cancer cells that T cells cannot eliminate.
- Immune checkpoint
- A molecule that suppresses the attack of immune cells. Blocking its function increases the ability of immune cells to attack cancer.
- Memory NK cells
- NK cells that differentiate after a viral infection, are long-lived, and can proliferate again. They attack target cells efficiently.
- CAR-NK cells
- NK cells that have been genetically modified to carry an artificial receptor protein (CAR) that recognizes cancer cells.
ResearchResearch themes
The lab aims to use NK cells to develop immunotherapies that can completely cure cancer. To this end, building on basic research that investigates the mechanisms of NK cell-mediated cancer immunity at the molecular level, it pursues translational research to strengthen NK cell cancer immunity.
*Illustrative imageExploring NK receptors and immune checkpoints
NK cells recognize cancer cells through many types of NK receptors. The lab identifies and characterizes unknown receptors and their ligands, as well as immune checkpoint molecules that suppress NK cell activity, and aims to develop drugs that target them.
*Illustrative imageMechanisms of differentiation into memory NK cells
The lab investigates at the molecular level how NK cells differentiate into memory NK cells, which live long and attack strongly. It has found that memory NK cells have strong attack ability against cancer cells, and aims to apply this property to cancer immunity.
*Illustrative imageDeveloping new NK cell immunotherapies
The lab is working to improve CAR-NK cell therapy, which treats cancer with genetically modified immune cells. It aims to develop improved CAR-NK cells that survive longer in the body, expand after encountering cancer cells, and attack more strongly.
MembersFaculty
The members of the Division of Tumor Immune Responses are the division head, unit head, senior researchers, researchers, research residents, technicians, voluntary trainees, graduate students from Nagoya University's collaborative graduate program, and secretaries.
- Affiliated ProfessorTsukasa Nabekura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Killer T cells surround a cancer cell” NIH Image Galle / CC BY-SA 4.0 (cropped)
- Exploring NK receptors and immune checkpoints: “CCR7 receptor” ·Solembum· / CC BY-SA 4.0 (cropped)
- Mechanisms of differentiation into memory NK cells: “Natural Killer Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Developing new NK cell immunotherapies: “Scientist checks cell culture flask on microscope” Peter Saxon / CC BY-SA 4.0 (cropped)
- Related lab (Immunodeficiency Regulation Lab): “US Navy 040427-N-0000W-028 Using protective gloves under a protective hood, civilian technician Erlin Listiyaningsih of the NAMRU-2 Laboratory, Jakarta, Indonesia, conducts specialized testing to identify a deadly pneumonia str” U.S. Navy photo by Tom Watanabe. / Public domain (cropped)
- Related lab (Target Discovery and Therapeutics (Tumor Regulation Division) Lab): “Mus musculus melanoma skin cancer cells in UFV” Mateus Figueiredo / CC BY 4.0 (cropped)
- Related lab (Advanced Targeted Cancer Therapeutics Lab): “Culture media” John Crawford (Photographer) / Public domain (cropped)
- Related lab (Cancer Pathophysiology Lab): “Researchers in laboratory” Rhoda Baer (Photographer) / Public domain (cropped)
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