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Immunodeficiency Regulation Lab
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The lab studies drug resistance in HIV infection and how the human host defends against the virus.
AboutAbout the lab
Unraveling HIV drug resistance and human defenses.
The Immunodeficiency Regulation Lab is a cooperative graduate chair of the Nagoya University Graduate School of Medicine that conducts research on HIV infection and AIDS.
The research takes place in the Department of Infectious Diseases and Immunology at the Clinical Research Center of Nagoya Medical Center, located in Sannomaru, Naka Ward, Nagoya. Taking advantage of being attached to a hospital, the lab conducts research that combines basic science and clinical practice.
At the molecular level, the lab investigates how HIV changes under antiviral drug treatment and escapes the drugs (drug resistance). It also works to clarify how the host (humans) deals with HIV, and applies these findings to the development of new therapeutic drugs.
The lab accepts graduate students (master's and doctoral programs in medical science), and researchers, physicians, and graduate students specializing in medicine, pharmacy, science, engineering, and other fields work together.
Key terms
- HIV
- Human immunodeficiency virus. Infection causes AIDS (acquired immunodeficiency syndrome)
- Drug resistance
- The process by which a virus changes and escapes the effect of antiviral drugs
- Host
- The organism that a virus infects. In this research, it refers to humans
- APOBEC3G
- A host factor protein in human cells that suppresses the replication of retroviruses
ResearchResearch themes
Treatment of AIDS/HIV infection still does not lead to a cure, and patients must keep taking drugs for a long time. To overcome future treatment difficulties caused by the emergence of drug-resistant viruses and by side effects, the lab studies how HIV escapes drugs and how the host responds.
*Illustrative imageEpidemiological surveillance of drug-resistant HIV
As part of research by the AIDS prevention research group of the Ministry of Health, Labour and Welfare, the lab operates a nationwide network for testing and surveillance of drug-resistant HIV. By testing and analyzing resistant viruses, it provides clinicians with information for choosing therapeutic drugs.
*Illustrative imageHIV-2 testing technology and surveillance
Because several HIV-2 infections, which had no precedent in Japan, were found in a short period, the lab is working to develop and improve nationwide testing technology. It has also independently established viral load measurement and drug resistance testing, which support treatment.
*Illustrative imageMechanisms of resistance to anti-HIV drugs
The lab investigates, from the perspectives of molecular biology and structural biology, how resistant viruses emerge against the anti-HIV drugs Darunavir, Raltegravir, and Maraviroc. This is joint research with the Nagoya University Graduate School of Engineering.
*Illustrative imageHost defense factors against HIV
Humans have a host factor, APOBEC3G (A3G), that suppresses the replication of retroviruses, but the HIV protein Vif leads it to degradation. Aiming at a new type of anti-HIV drug that blocks the binding between Vif and A3G, the lab works to elucidate A3G and to search for inhibitors.
MembersFaculty
- Affiliated Associate ProfessorMayumi Imahashi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “US Navy 040427-N-0000W-028 Using protective gloves under a protective hood, civilian technician Erlin Listiyaningsih of the NAMRU-2 Laboratory, Jakarta, Indonesia, conducts specialized testing to identify a deadly pneumonia str” U.S. Navy photo by Tom Watanabe. / Public domain (cropped)
- Epidemiological surveillance of drug-resistant HIV: “Antiretroviral Drugs to Treat HIV Infection ( )” NIAID / CC BY 2.0 (cropped)
- HIV-2 testing technology and surveillance: “Clinical Pathology Blood Testing Laboratory in Navi Mumbai, India” Goleisureintl / CC BY 4.0 (cropped)
- Mechanisms of resistance to anti-HIV drugs: “Molecular ball-and-stick model of Perflubron, overlayed with electron-density coded VdW model” Piswind / CC BY-SA 3.0 (cropped)
- Host defense factors against HIV: “Protein APOBEC3G PDB 2JYW” Pleiotrope / Public domain (cropped)
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