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Target Discovery and Therapeutics (Tumor Regulation Division) Lab
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A lab that investigates cancer as a breakdown of cellular homeostasis.
AboutAbout the lab
Viewing cancer as a breakdown of cellular homeostasis
The Target Discovery and Therapeutics Lab (Tumor Regulation Division) studies cancer at the Aichi Cancer Center Research Institute as a breakdown in the maintenance of cellular homeostasis.
Normal cells maintain their state by strictly controlling proliferation and movement, but when abnormalities occur in signaling molecules, this leads to uncontrolled proliferation, invasion, and metastasis.
By clarifying these mechanisms and acting on them with drugs and other means, the lab aims to present new leads for diagnosis and treatment.
The lab is located at Aichi Cancer Center (Chikusa-ku, Nagoya), and the division head serves as an affiliated professor at Nagoya University Graduate School of Medicine.
Key terms
- Src
- An enzyme that attaches phosphate tags to tyrosine residues of proteins. It was the first oncogene product to be discovered and is located just beneath the cell membrane
- Exosomes
- Small capsule-like membrane vesicles that cells release to the outside. The signaling molecules inside them change the function of the cells that receive them
- Lipid rafts
- Tiny regions in the cell membrane. They spatially control signaling molecules on the membrane
NewsLab news
View More ↗ResearchResearch themes
The lab aims to clarify the mechanisms of homeostasis maintenance that are broken down in cancer cells, and to develop new treatment strategies that prevent cancer cells from becoming malignant by acting on them with drugs and other means. Starting from Src, a signaling molecule that was the first oncogene product to be identified, the lab searches for new molecular targets.
*Illustrative imageMechanisms of extracellular vesicle secretion in cancer
The lab studies how the amount and quality of exosomes released by cancer cells are controlled. It has shown that Src and stress granules are involved in secretion, and has also created a cell system in which the amount secreted can be measured by luminescence.
*Illustrative imageLipid rafts and the Src-Fer pathway
The lab has studied how lipid rafts in the cell membrane control Src signaling and has found Fer kinase to be a key player. It has also obtained a compound that binds to Fer, has low toxicity to normal cells, and suppresses the proliferation of cancer cells.
*Illustrative imageSignal regulation by microRNAs
The lab searches for microRNAs related to cancer traits caused by abnormal signaling, and for their target genes. It has found microRNAs that are controlled by Src signaling and ones that control Src itself, which may lead to new treatment strategies for drug-resistant cancers.
MembersFaculty
The members of the Target Discovery and Therapeutics (Tumor Regulation Division) Lab consist of the division head, a unit head, researchers, research residents, institute technicians, and cooperative graduate students.As of 2026
- Affiliated ProfessorChitose Oneyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mus musculus melanoma skin cancer cells in UFV” Mateus Figueiredo / CC BY 4.0 (cropped)
- Mechanisms of extracellular vesicle secretion in cancer: “Exosome with hsp70” Guillaume Pelletier / CC BY-SA 4.0 (cropped)
- Lipid rafts and the Src-Fer pathway: “Cell Membrane” Blackout Sea / CC0 (cropped)
- Signal regulation by microRNAs: “XBio illustration – Gene Regulation” explorebiology / CC BY 4.0 (cropped)
- Related lab (がん病態生理学): “Researchers in laboratory” Rhoda Baer (Photographer) / Public domain (cropped)
- Related lab (老化代謝科学): “Visit to Yee Hong Centre for Geriatric Care ( )” Rocco Rossi / CC BY 2.0 (cropped)
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