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Advanced Targeted Cancer Therapeutics Lab
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The lab develops molecularly targeted therapies and takes on cancers with KRAS mutations.
AboutAbout the lab
Telling apart patients who respond to treatment from those who do not, and exploring new therapies.
The Advanced Targeted Cancer Therapeutics lab researches the development of molecularly targeted therapies, which treat cancer by targeting the characteristics of cancer cells.
Focusing in particular on cancers with mutations in the KRAS gene, the lab investigates which patients should receive which drugs and how, and why drugs stop working.
By combining analyses of cancer cells, animal models, and patient specimens, the lab aims to discover new therapeutic targets and develop ways to make existing treatments more effective.
On the lab's website, it is introduced under the name "Division of Translational Research for Targeted Cancer Therapy" of the Aichi Cancer Center Research Institute.
Key terms
- Molecularly targeted therapy
- A treatment that targets the molecules driving the growth of cancer cells and administers drugs that act on them.
- KRAS
- A gene found to be mutated in about 20% of all cancers. For a long time, no effective drugs had been developed against it.
- Circulating tumor DNA
- DNA that has leaked from cancer cells into the blood. Also called ctDNA.
NewsLab news
View More ↗ResearchResearch themes
The introduction of molecularly targeted therapy has greatly changed cancer drug therapy, but some targets are still difficult to develop drugs for, and drugs can stop working over time. The lab combines analyses of cancer cells, animal models, and patient specimens to discover new therapeutic targets and develop ways to make existing treatments more effective.
*Illustrative imageExploring how to use KRAS inhibitors
The lab aims to clarify which patients should receive KRAS inhibitors and how they should be used, by combining studies of cancer cells, animal models, and patient specimens.
*Illustrative imageElucidating how drugs stop working
When molecularly targeted drugs are used over a long period, cancer cells can become resistant to them. Uncovering the mechanisms of resistance and proposing new treatments is another key pillar of the lab.
*Illustrative imageNew methods for evaluating circulating tumor DNA
The lab aims to develop new evaluation methods for circulating tumor DNA (ctDNA), which has leaked from cancer cells into the blood, by analyzing ctDNA and tumors obtained from a large-scale clinical trial of colorectal cancer led mainly by the National Cancer Center.
MembersFaculty
The members of the Division of Translational Research for Targeted Cancer Therapy are the division head, senior researchers, researchers, institute technicians, specialists, research residents, and graduate students.
- Division HeadHiromichi Ebi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Culture media” John Crawford (Photographer) / Public domain (cropped)
- Exploring how to use KRAS inhibitors: “KRAS protein 3GFT” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Elucidating how drugs stop working: “Petri Dish or Culture Plate containing agar medium used for stool culture” Frankincense Diala / CC0 (cropped)
- New methods for evaluating circulating tumor DNA: “DNA double helix ( )” Genomics Education Programme / CC BY 2.0 (cropped)
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