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Cancer Pathophysiology Lab
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A lab that uses mice to study the mechanisms of cancer metastasis and cachexia.
AboutAbout the lab
Exploring cancer from onset to metastasis in mice
The Division of Cancer Pathophysiology studies how cancer arises in the body, becomes malignant and metastasizes, and how cancer affects the body.
The division is part of the Aichi Cancer Center Research Institute, and students can also conduct research here as cooperative graduate students of Nagoya University Graduate School.
Using genetically modified mice, the lab focuses on the tumor microenvironment, the mechanisms of metastasis, and cancer cachexia.
Working with the departments of Aichi Cancer Center Hospital, the lab aims to turn the results of basic research into new treatments.
Key terms
- Tumor microenvironment
- The region that includes cancer cells and the normal cells surrounding them. It is thought to assist the growth, invasion, and metastasis of cancer
- Epithelial-mesenchymal transition
- A phenomenon in which cancer cells arising on the surface of the colon disrupt the orderly arrangement of the cells around them
- Cancer cachexia
- A condition seen in many cancer patients in which muscles waste away and body weight declines
ResearchResearch themes
The lab views cancer as a systemic disease and studies, at the whole-organism level, how cancer cells interact with the normal cells around them, how metastasis occurs, and how cancer affects the body. Mainly using mouse models of cancer created by genetic modification or transplantation, the lab aims to create new cancer medicine.
*Illustrative imageResearch on the tumor microenvironment
The tumor microenvironment is the region that includes cancer cells and the normal cells surrounding them. Using mice that spontaneously develop colorectal cancer, the lab has found that cancer cells also make use of normal cells in this environment when they acquire drug resistance.
*Illustrative imageA protein that suppresses colorectal cancer metastasis
The lab has identified that a protein called HNRNPLL suppresses the metastasis of colorectal cancer cells. It has also found that when epithelial-mesenchymal transition occurs, the level of this protein falls, making invasion into surrounding tissue and metastasis to the lungs more likely.
*Illustrative imageResearch on cancer cachexia
Cancer cachexia is a condition in which cancer causes weight loss and progressive muscle weakness. Using mouse models of cancer cachexia, the lab is working to clarify how inflammatory cytokines and other factors bring about this condition.
MembersFaculty
The members of the Cancer Pathophysiology Division consist of the division head, a principal researcher, research residents, institute technicians, cooperative graduate students, and a secretary.
- Affiliated ProfessorMasahiro Aoki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Researchers in laboratory” Rhoda Baer (Photographer) / Public domain (cropped)
- Research on the tumor microenvironment: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- A protein that suppresses colorectal cancer metastasis: “Myoglobin” →AzaToth / Public domain (cropped)
- Research on cancer cachexia: “Cancer de pulmon” Modificado de OpenStax College / CC BY-SA 3.0 (cropped)
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