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Aging Metabolic Science Lab
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The lab investigates how diabetes and obesity are related to sarcopenia and dementia.
AboutAbout the lab
Exploring sarcopenia and dementia starting from diabetes and obesity.
The Aging Metabolic Science Lab is introduced on the page of the Department of Metabolism and Endocrinology at the National Center for Geriatrics and Gerontology (Obu City, Aichi Prefecture).
As diabetes becomes more common among older adults, sarcopenia (loss of muscle) and dementia are increasing rapidly. The lab studies how these conditions progress, indicators for detecting them early, and methods for preventing them.
The lab conducts research based on a cohort it built itself, as well as analyses using mice.
Key terms
- Sarcopenia
- A condition in which muscle mass and function decline. Diabetes is considered a risk factor
- Cohort
- A research method in which the health of people in the same group is followed over time to explore the relationship with disease onset
- TREM2
- A receptor on the surface of monocytes and microglia. It is involved in clearing amyloid-β from the brain
NewsLab news
A paper by Director Asahara was published in Front Nutr
A paper by Director Asahara and colleagues was published in Diabetes Obes Metab
A paper by Deputy Director Omura was published in a journal of the American Diabetes Association
Press release on the usefulness of muscle quality assessment and phase angle
ResearchResearch themes
The lab aims to clarify how sarcopenia and dementia caused by diabetes and obesity progress, and to develop indicators for early prediction and strategies for prevention. In addition to cohort studies of people, the lab also conducts analyses using mice.
*Illustrative imageDiabetes, obesity, and sarcopenia
The lab studies the mechanisms by which sarcopenia progresses in people with diabetes or obesity, and aims to develop indicators for early detection and methods for prevention. Based on its own cohort, the lab has reported a measurement method focusing on abdominal muscle mass and a diagnostic index that combines waist circumference with muscle quality.
*Illustrative imageEarly prediction of dementia in diabetes and obesity
Focusing on TREM2, the lab is working to develop indicators for early prediction and methods for prevention of dementia in people with diabetes or obesity. Cohort studies have shown that soluble TREM2 in the blood is associated with cognitive decline and with the future risk of dementia.
MembersFaculty
- Affiliated ProfessorSatoko Asahara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Visit to Yee Hong Centre for Geriatric Care ( )” Rocco Rossi / CC BY 2.0 (cropped)
- Diabetes, obesity, and sarcopenia: “(20250417) Blood glucose meter 09” Roy Zuo / CC BY-SA 4.0 (cropped)
- Early prediction of dementia in diabetes and obesity: “Insulin struct” User:AtikaAtikawa / CC BY-SA 4.0 (cropped)
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