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Tokyo University of Science

Undergraduate: Faculty of Science and Technology, Department of Biological Science and Technology

Graduate: Graduate School of Science and Technology, Department of Biological Science and Technology

発生生物学（和田研究室）

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骨格の形づくりと再生を遺伝子から数理モデルまで探る研究室。

Skeletal morphogenesisOrgan regenerationMathematical models

骨の標本 — *Illustrative image. Not taken at the lab.

AboutAbout the lab

骨格の形はどう決まり、どう再生するのか。

和田研究室は、脊椎動物の骨格の形がどのようにして作られるのかを研究しています。
骨格を作る細胞の移動や接着、増殖、分化は、発生の時期や場所に応じて正確に調節されています。
同じような調節のしくみは、器官が再生する過程でも働くと考えられています。
遺伝子から細胞、組織、器官までの複数の視点に加え、数理モデルも使って調べています。

Key terms

形態形成: 発生の過程で、生き物の体や器官の形ができあがる現象。
分化: 細胞が、役割の異なる細胞に変わっていく過程。
数理モデル: 現象のしくみを数式などで表し、形の変化を再現したり予測したりする方法。

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ResearchResearch themes

脊椎動物の形は、骨や軟骨など骨格の形で決まります。この研究室では、形態形成や再生の過程で起こる細胞のふるまいを調節するしくみを、遺伝子から器官までの複数の視点で、また数理モデルを併用して調べています。

*Illustrative image

骨格の形づくりと再生の仕組み

骨格を作る細胞の移動、接着、増殖、分化が、発生の時期や場所に応じて調節されるしくみを調べます。同じような調節は器官の再生でも働くと考えられており、数理モデルも併用します。

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MembersFaculty

Professor和田直之

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About the images

The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).

Top image: “Regeneration of bones” Jacques Christophe Werner (1798–1856) / Public domain (cropped)
骨格の形づくりと再生の仕組み: “Scientist checks cell culture flask on microscope” Peter Saxon / CC BY-SA 4.0 (cropped)
Related lab (がん細胞生物学（定家研究室）): “Telomeres” AJC1 / CC BY-SA 4.0 (cropped)
Related lab (応用微生物学（荒添研究室）): “Fission yeast (Schizosaccharomyces pombe)” Database Center for Life Science (DBCLS) / CC BY 3.0 (cropped)

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