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Nanobioscience (Masaike Lab)
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A lab that links structural change, reaction, and function, from single molecules to tissues.
AboutAbout the lab
Measuring one molecule or cell at a time
The lab studies how the unit structures at each level, from a single enzyme molecule up to tissues, carry out their functions.
The lab records video with modified microscopes and combines it with biochemical measurements to examine the causal relationships among structural change, reaction, and function.
The lab aims to apply this work to elucidating respiratory diseases and developing highly sensitive biodevices.
Key terms
- Motor protein
- A protein that uses energy to generate movement. The lab observes structural changes in F1-ATPase.
- Cilia
- Thin, hair-like structures on the surface of cells. The lab studies their motion in living cells of the tracheal epithelium.
- Biosensor
- A device that detects substances by using the reactions of biomolecules. The lab works with a device that measures phosphate with high sensitivity.
ResearchResearch themes
The lab aims to elucidate how the unit structures at each level, from a single enzyme molecule to tissues, carry out their functions. Using video recording with modified microscopes together with biochemical measurements, it seeks to understand the causal relationships among structural change, reaction, and function as a story with temporal and spatial dimensions and quantitative grounding.
Single-molecule observation of F1-ATPase
The lab observes structural changes in the motor protein F1-ATPase at the single-molecule level.
*Illustrative imageCiliary motion in tracheal epithelial cells
The lab analyzes the motion of cilia in three dimensions in living cells of the tracheal epithelium.
*Illustrative imagePhosphate biosensor
Using a highly sensitive phosphate biosensor device, the lab measures the reactions caused by enzymes one molecule at a time.
MembersFaculty
- Associate ProfessorTomoko Masaike
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Atp synthase (simplified Chinese)” Atp_synthase.PNG: Alex.X derivative work: IgniX (talk) / CC BY-SA 3.0 (cropped)
- Ciliary motion in tracheal epithelial cells: “Ciliated epithelium of the intestine Anodonta” Arbucksme / CC BY-SA 4.0 (cropped)
- Phosphate biosensor: “DNA microarray chip” ErikAbner / CC BY 4.0 (cropped)
- Related lab (がん細胞生物学
（定家 研究室） ): “Telomeres” AJC1 / CC BY-SA 4.0 (cropped) - Related lab (植物分子生理学
（朽津 研究室） ): “Tomato Leaf Mold” Elizabeth Bush, Virginia Polytechnic Institute and State University / CC BY 3.0 (cropped) - Related lab (植物成長発生学
（西浜 研究室） ): “Marchantia polymorpha - Common Liverwort 01” Jasper Shide / CC0 (cropped) - Related lab (発生生物学
（和田 研究室） ): “Regeneration of bones” Jacques Christophe Werner (1798–1856) / Public domain (cropped)
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