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Cancer Cell Biology (Sadaie Lab)
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A lab searching for the weaknesses of cancer cells and creating methods to suppress them.
AboutAbout the lab
Finding the weaknesses of cancer cells and leading to the development of methods to suppress cancer.
The Sadaie Lab (Cancer Cell Biology) conducts basic biological research to find the weaknesses of cancer cells and lead to the development of methods to suppress cancer.
The lab pursues two main lines of research: one targeting the mechanisms that maintain telomeres at the ends of chromosomes, and one using methods that drive cells into cellular senescence.
The lab also takes an approach that drives target cells not only to death but into senescence.
Key terms
- Telomere
- Telomere: a complex of special proteins and DNA at both ends of a chromosome that protects the chromosome.
- ALT
- ALT mechanism (alternative lengthening of telomeres): a way of maintaining telomeres that uses DNA homologous recombination.
- Cellular senescence
- Cellular senescence: the irreversible halt of cell proliferation while the cell remains alive.
NewsLab news
Review article on cellular senescence published in "Hifuka" (Dermatology)
Collaborative research results accepted for publication in Proc. Natl. Acad. Sci. USA
A doctoral student wins the Outstanding Student Presentation Award at the Hokuriku Epigenetics Research Meeting
Research results published in Cancer Science (press release available)
ResearchResearch themes
Although the characteristics of cancer have become clearer, some cancers still have no specific treatment. The Sadaie Lab uses basic biological approaches to look for the weaknesses of cancer, aiming to discover therapeutic targets and develop treatments.
*Illustrative imageTelomere Maintenance Mechanisms and Cancer Suppression
The lab searches for ways to suppress cancer by targeting the telomere maintenance mechanisms that cancer cells use to keep proliferating. It focuses on cancers that proliferate through the ALT mechanism, which uses DNA homologous recombination, and studies how compounds that inhibit this mechanism work.
*Illustrative imageCancer Suppression Using Cellular Senescence
The lab studies the mechanism of cellular senescence, in which cells stop proliferating while remaining alive, and searches for drugs that induce it. In collaboration with Cancer Research UK, it selected compounds that cause the changes in nuclear shape characteristic of senescent cells.
MembersFaculty
The members of the Sadaie Lab consist of faculty and students in the doctoral, master's, and undergraduate programs.As of 2026
- ProfessorMahito Sadaie
- Assistant ProfessorYukiko Kojima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Telomeres” AJC1 / CC BY-SA 4.0 (cropped)
- Telomere Maintenance Mechanisms and Cancer Suppression: “Telomeres transparent” AJC1 / CC BY-SA 4.0 (cropped)
- Cancer Suppression Using Cellular Senescence: “Cellular senescence” Velichko Artem / CC BY 4.0 (cropped)
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（西浜 研究室） ): “Marchantia polymorpha - Common Liverwort 01” Jasper Shide / CC0 (cropped) - Related lab (発生生物学
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