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Applied Microbiology (Arazoe Lab)
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A lab that explores microbial survival strategies and breeding, starting from the development of genome editing technology for microbes.
AboutAbout the lab
Opening up genome editing in microbes
The lab centers its research on developing new tools and technologies for genome editing in microbes.
In microbes, genome editing has not yet had as much impact as it has in animals and plants.
The lab aims to elucidate at the molecular level the arms races between plants and pathogens, between insects and pathogens, and between viruses and microbes.
In addition, the lab aims to draw out the capabilities of microbes through genome editing technology and to contribute to the microbial bio-industry in food, agriculture, the environment, and medicine.
Key terms
- Genome editing
- Technology for freely modifying genome information, the blueprint of life.
- CRISPR/Cas9
- An RNA-guided genome editing tool. It applies the acquired immunity mechanism against foreign nucleic acids found in bacteria and archaea.
- TALEN
- A protein-based genome editing tool. It is a modified version of the TAL effectors released by plant pathogenic bacteria.
ResearchResearch themes
The lab aims to develop new tools and technologies for genome editing in microbes and to pioneer post-genome research unique to microbes. It also aims to clarify at the molecular level the interactions between organisms involving microbes, as well as the usefulness of microbes.
*Illustrative imageDeveloping genome editing tools for microbes
RNA-guided CRISPR/Cas9 sometimes fails to edit microbes as expected. The lab develops new tools and technologies to overcome this barrier, and contributes to putting them to practical use in society in cooperation with MycoGenome Co., Ltd., a startup spun out of Tokyo University of Science.
*Illustrative imageMicrobial survival strategies and interactions
The genome editing tool TALEN is a modified version of the TAL effectors released by plant pathogenic bacteria. Aiming to elucidate such attack-and-defense between organisms at the molecular level, the lab also focuses on the survival strategies of eukaryotic microbes that have lost sexual reproduction.
*Illustrative imageMolecular breeding of microbes
The lab clarifies at the molecular level the capabilities of microbes involved in the fermentation of yogurt, edible mushrooms, sake, miso, and soy sauce, and in the production of useful substances. Using its own original genome editing technology and synthetic biology approaches, it draws out those capabilities, aiming to contribute to food, agriculture, the environment, and medicine.
MembersFaculty
- LecturerTakayuki Arazoe
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fission yeast (Schizosaccharomyces pombe)” Database Center for Life Science (DBCLS) / CC BY 3.0 (cropped)
- Developing genome editing tools for microbes: “CRISPR-Cas9 Editing of the Genome ( )” National Human Genome Research Institute (NHGRI) / CC BY 2.0 (cropped)
- Microbial survival strategies and interactions: “Lactose fermenting (pink) and non-lactose fermenting colonies of bacteria on CLED agar” Ajay Kumar Chaurasiya / CC0 (cropped)
- Molecular breeding of microbes: “Yeast Cell Diagram Illustration” Morganocyte / CC BY-SA 4.0 (cropped)
- Related lab (がん細胞生物学
（定家 研究室） ): “Telomeres” AJC1 / CC BY-SA 4.0 (cropped) - Related lab (植物分子生理学
（朽津 研究室） ): “Tomato Leaf Mold” Elizabeth Bush, Virginia Polytechnic Institute and State University / CC BY 3.0 (cropped) - Related lab (植物成長発生学
（西浜 研究室） ): “Marchantia polymorpha - Common Liverwort 01” Jasper Shide / CC0 (cropped)
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