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Disease Systems Medicine Lab
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A lab investigating the mechanisms of lifestyle-related diseases through chronic inflammation and communication between organs.
AboutAbout the lab
Searching for the common foundation of many diseases.
The lab studies the mechanisms underlying disease that are shared across lifestyle-related diseases and cancer.
It aims to clarify the basis of multimorbidity, in which a person has several conditions such as heart failure, diabetes, and chronic kidney disease, and to apply the findings to diagnosis and treatment.
Focusing on chronic inflammation and metabolic changes, the lab has also found that immune cells such as macrophages help maintain the state of organs such as the heart.
It studies how the metabolic, immune, nervous, and circulatory systems work together to keep the body healthy, and how this changes with aging.
Key terms
- Chronic inflammation
- A state in which mild inflammation continues for a long time. It causes few noticeable symptoms but forms the foundation of many diseases
- Macrophage
- An immune cell found throughout the body. Besides engulfing foreign material, it also helps maintain the tissue of each organ
- Multimorbidity
- A condition in which one person has several chronic diseases at the same time
- Hematopoietic stem cell
- A cell in the bone marrow that gives rise to all types of blood cells, including red and white blood cells
NewsLab news
View More ↗ResearchResearch themes
The lab studies chronic inflammation and metabolic changes, which form a common foundation of disease in lifestyle-related diseases and cancer. It investigates how hematopoietic, immune, nervous, metabolic, and endocrine systems work together to help the body cope with stress, and how a disease that starts in one organ spreads to others.
*Illustrative imageStress Memory in Hematopoietic Stem Cells
The lab has shown that hematopoietic stem cells remember the stress of heart failure, and that this memory causes later worsening of heart failure and the onset of other diseases.
*Illustrative imageMacrophages That Maintain the Heart's Rhythm
The lab has found that macrophages in the heart control how electrical impulses are conducted, and thereby maintain the heart's normal contraction rhythm.
*Illustrative imageCommunication Among the Heart, Brain, and Kidneys
The lab studies how a network linking the heart, brain, and kidneys protects the heart from stress and maintains its condition.
MembersFaculty
The lab's members consist of faculty, laboratory assistants, graduate students, and undergraduate students.As of 2024
- ProfessorIchiro Manabe
- Project Assistant ProfessorFujimi Kudo
- Project Assistant ProfessorYuichiro Nakata
- Project Assistant ProfessorKatsutoshi Imamura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Medical Research Council, Laboratory of Molecular Biology - geograph.org.uk - 3018493” David P Howard / CC BY-SA 2.0 (cropped)
- Stress Memory in Hematopoietic Stem Cells: “NABL Accredited Pathology Lab and Diagnostic Centre in Kharghar, Navi Mumbai - Full Body Checkup, CBC, Thyroid Blood Test and Home Blood Collection” Goleisureintl / CC BY 4.0 (cropped)
- Macrophages That Maintain the Heart's Rhythm: “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Communication Among the Heart, Brain, and Kidneys: “Heart Anatomy Model ( )” YVC Biology Department / CC BY 2.0 (cropped)
- Related lab (Metabolic Physiology Lab): “Insulin glulisine 6GV0 spacefill” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Related lab (Molecular Pathophysiology and Analysis Lab): “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Related lab (Immune Development Lab): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (International Allergy and Mucosal Immunology Lab): “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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