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International Allergy and Mucosal Immunology Lab
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A lab that studies immunity operating in the mucosa of the gut and airways, and seeks ways to suppress allergy and inflammation.
AboutAbout the lab
The mucosa: the body's front-line defense system.
The International Allergy and Mucosal Immunology Lab studies the mechanisms of immunity that operate in mucosal tissues such as the intestinal tract and airways.
The mucosa blocks the entry of pathogens while selectively accepting nutrients and commensal microorganisms.
When this regulation breaks down, it is thought to lead not only to infections but also to allergies and autoimmune diseases.
The lab aims to unravel how immune cells interact with their surrounding environment and to create new therapies.
Key terms
- Mucosal immunity
- Immune mechanisms that operate in mucosal sites in contact with the outside world, such as the gut and airways
- Mesenchymal cells
- Cells that support the structure of tissues. They have also been found to be involved in the function of immune cells
- Mast cells
- Immune cells that store histamine and other substances. They trigger allergic reactions
NewsLab news
View More ↗ResearchResearch themes
The lab seeks ways to suppress allergic and inflammatory diseases by understanding the tissue microenvironment and the connections between organs in mucosal immunity. With an eye toward everything from basic research to clinical application, it is running three projects.
*Illustrative imageCreating treatments from mesenchymal cells
The lab has shown that mesenchymal cells, long thought to merely support tissues, give immune cells tissue-specific properties and take part in regulating the mucosal barrier, tissue repair, fibrosis, and inflammation. By studying interactions between the mesenchymal and nervous systems, it is exploring the origins of mucosal repair and fibrosis.
*Illustrative imageProtecting the gut through organ crosstalk
The lab focuses on organ crosstalk, in which multiple organs coordinate to regulate the gut environment, and examines the mechanisms at the molecular and cellular levels. It found that the invasion of tissues by gut bacteria involved in inflammatory bowel disease is controlled through coordination among multiple organs.
*Illustrative imageThe immune switch of allergy
The lab searches for the mechanism that switches the immune activity causing allergic reactions from ON to OFF. Focusing on the plasticity of mast cells, which have long been regarded as the "bad guys" and change their properties depending on the surrounding environment, it investigates ways to steer them toward a state that suppresses allergy.
MembersFaculty
The members of the International Allergy and Mucosal Immunology Lab consist of faculty, graduate students, researchers, and students from the Department of Medicine in the School of Medicine.
- ProfessorYosuke Kurashima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Creating treatments from mesenchymal cells: “Indian Muntjac fibroblast cells ( )” ZEISS Microscopy / CC BY 2.0 (cropped)
- Protecting the gut through organ crosstalk: “Bacteria on agar plate” HansN. / CC BY-SA 3.0 (cropped)
- The immune switch of allergy: “Mast cells in bone marrow” Vortioxetine / CC BY-SA 4.0 (cropped)
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病態制御学): “3D structure of secretory IgA2” McortNGHH / CC BY-SA 4.0 (cropped) - Related lab (代謝生理学): “Insulin glulisine 6GV0 spacefill” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Related lab (先端データ医科学): “Illumina Hiseq 2000 sequencers, BGI Hong Kong sequencing room” Scotted400 / CC BY 3.0 (cropped)
- Related lab (疾患システム医学): “Medical Research Council, Laboratory of Molecular Biology - geograph.org.uk - 3018493” David P Howard / CC BY-SA 2.0 (cropped)
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