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Molecular Pathophysiology and Analysis Lab
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A lab that reads cancer and metabolic diseases through the epigenome and RNA.
AboutAbout the lab
Aiming to bridge basic and clinical research
The lab investigates the molecular mechanisms of cancer, immunity, endocrine and metabolic diseases, and cardiovascular diseases.
Aiming to bridge basic and clinical research, the lab pursues translational research that leads to practical applications.
Using technologies such as ES and iPS cells, CRISPR/Cas9, next-generation sequencing, single-cell analysis, and proteomics, the lab conducts comprehensive research from cells to animal models.
It is a hybrid lab where basic researchers come together with specialists who treat patients in endocrinology and metabolism, cardiology, and surgery.
Key terms
- Epigenetics
- Mechanisms that change how readily genes are read without changing the DNA sequence.
- Single-cell analysis
- A method of separating cells one by one and examining gene activity in each.
- lncRNA
- Long RNA that is not translated into protein. It regulates gene activity.
ResearchResearch themes
The lab analyzes molecular regulation inside cells in an integrated way, extending to the levels of epigenetics and RNA. It aims to clarify how cancer and metabolic diseases arise and to lead to the development of new diagnostic and therapeutic methods.
*Illustrative imageFactors that determine the malignant progression of tumors
Using single-cell analysis, the lab investigates molecular regulation in cells in an integrated way, from transcriptional regulation including epigenetics to the RNA level. It aims to clarify how diseases arise and the mechanisms behind them.
*Illustrative imageCancer, lifestyle-related diseases, and aging
Centered on cancer and metabolic diseases, the lab advances next-generation molecular pathology analysis that incorporates new methodologies, so that medicine can be tailored to each individual's genome.
*Illustrative imageChallenging pluripotent stem cells
p53 is known to act to suppress the generation of pluripotent clones. The lab has identified a new lncRNA that functions in a p53-dependent manner and is analyzing its function.
MembersFaculty
The members of the lab are faculty, collaborators, graduate students, research students, technical assistants, and administrative assistants.As of 2025
- ProfessorTomoaki Tanaka
- Project Associate ProfessorIkki Sakuma
- Project LecturerRyota Kurimoto
- Assistant ProfessorMasataka Yokoyama
- Assistant ProfessorNaoko Hashimoto
- Project Assistant ProfessorAkitoshi Nakayama
- Project Assistant ProfessorMasanori Fujimoto
- Project Assistant ProfessorTakashi Kono
- Project Assistant ProfessorTakahiro Fuchigami
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Factors that determine the malignant progression of tumors: “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Cancer, lifestyle-related diseases, and aging: “Factsheet metabolic syndrome” Abduzhabborov / CC BY-SA 4.0 (cropped)
- Challenging pluripotent stem cells: “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (Disease Systems Medicine Lab): “Medical Research Council, Laboratory of Molecular Biology - geograph.org.uk - 3018493” David P Howard / CC BY-SA 2.0 (cropped)
- Related lab (Endocrinology, Metabolism, and Geriatric Medicine Lab): “Diabetes health cheack” Ofek Abuhazira / CC BY-SA 4.0 (cropped)
- Related lab (Metabolic Physiology Lab): “Insulin glulisine 6GV0 spacefill” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Related lab (Pediatrics Lab): “Haende-30” Matthias Süßen / CC BY-SA 3.0 (cropped)
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