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Innovative Regenerative Medicine Lab
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A lab building next-generation regenerative medicine with its own technology for rejuvenating cells.
AboutAbout the lab
From cell rejuvenation and blood formation to regenerative medicine.
The lab conducts research and development on next-generation regenerative medicine.
It has developed its own reprogramming technology that rejuvenates differentiated cells back into a progenitor cell state.
In parallel, it studies how blood is produced (hematopoiesis), aiming to understand and control the process.
By linking cell rejuvenation with an understanding of hematopoiesis, the lab aims to advance regenerative medicine and overcome blood diseases.
Key terms
- Reprogramming
- A procedure that returns a cell whose role has already been determined to a cell of an earlier stage
- Hematopoietic stem cell
- A cell that gives rise to all types of blood cells, including red and white blood cells
- Megakaryocyte
- A large cell in the bone marrow that produces platelets by breaking off into fragments
ResearchResearch themes
Built on understanding and controlling cell rejuvenation and hematopoiesis, the lab aims to advance regenerative medicine and overcome blood diseases. It pursues two areas: its original progenitor cell reprogramming technology, and human hematopoietic stem cell biology.
*Illustrative imageProgenitor Cell Reprogramming
This is the lab's original technology for rejuvenating differentiated cells back into a progenitor cell state, restoring their high proliferative capacity and function. The lab applies it to anticancer therapy with immune cells rendered non-aging, an iPS cell-based model of atherosclerosis, bone and cartilage regeneration, and wound healing and tissue regeneration.
*Illustrative imageHuman Hematopoietic Stem Cell Biology
This research seeks to understand the essence of hematopoiesis and to lay the foundation for overcoming blood diseases and for regenerative medicine. The lab investigates the mechanisms controlling self-renewal and expansion of hematopoietic stem cells, epigenome evaluation of myeloid neoplasms, how megakaryocytes are generated, and the role of immune-type megakaryocytes.
MembersFaculty
The lab's members consist of faculty, foreign research fellows, doctoral students, technical assistants, and administrative assistants.As of 2026
- ProfessorNaoya Takayama
- Project Assistant ProfessorSiJing Chen
- Project LecturerKentaro Kosaka
- Project Assistant ProfessorMichiaki Mukai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Progenitor Cell Reprogramming: “XBio illustration – Induced Pluripotent Stem Cells (iPSCs)” explorebiology / CC BY 4.0 (cropped)
- Human Hematopoietic Stem Cell Biology: “Nucleated red blood cell (RBC) in a Wright's stained peripheral blood smear (PBS) microscopy of an aplastic anemia patient” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse MOB three color” Matt Valley / Public domain (cropped)
- Related lab (Cellular and Molecular Medicine Lab): “Molecular Biology Laboratory, reflections - geograph.org.uk - 3763234” John Sutton / CC BY-SA 2.0 (cropped)
- Related lab (Endocrinology, Metabolism, and Geriatric Medicine Lab): “Diabetes health cheack” Ofek Abuhazira / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Pathophysiology and Analysis Lab): “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
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