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Functional Morphology Lab
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The lab studies how nerve fibers connect in the human brain to understand the mechanisms of cognition.
AboutAbout the lab
From the brain's wiring diagram to the mechanisms of cognition.
The Functional Morphology Lab investigates how nerve fibers are connected in the human brain, with the aim of understanding the mechanisms of cognitive function.
The lab combines white matter dissection using the Klingler method with brain imaging such as tractography and fMRI.
It has reported, among other findings, that the thalamus is a connector hub linking subnetworks of the cerebral cortex.
The lab also works to clarify the pathology of cerebral infarction and amyotrophic lateral sclerosis (ALS).
Key terms
- White matter
- The part of the brain where nerve fibers run in bundles
- Tractography
- A method that uses MRI images to depict how nerve fibers run in the brain
- Connector hub
- A part of the brain that connects many smaller networks to one another
ResearchResearch themes
The lab aims to elucidate the structural networks of the human brain that reflect cognitive function. Centered on analysis of fiber tract networks that combines white matter dissection with brain imaging, it also works to clarify the pathology of cerebral infarction and ALS.
*Illustrative imageAnalysis of Fiber Tract Networks
Using white matter dissection by the Klingler method together with tractography and fMRI, the lab analyzes cognitive function from the fiber tract networks of the human brain. It has reported that the thalamus is a connector hub for subnetworks of the cerebral cortex, the fiber tract network of the precuneus, and the identification of a new association fiber tract.
*Illustrative imagePathology of Cerebral Infarction
The lab studies the long-lasting inflammation in the brain after cerebral infarction and the microenvironment of the scar. It has reported that type III collagen forms a fibrous network in the ischemic core and may act as a "dynamic scaffold" for vascular remodeling and microglia.
*Illustrative imageOnset Mechanisms of ALS
The lab analyzes the function of FUS/TLS, a causative gene of familial ALS, to investigate how the disease develops. It focuses on the mechanism of shuttling between the nucleus and the cytoplasm, and on the process by which pathological aggregates form in the cytoplasm.
MembersFaculty
The members of the Functional Morphology Lab consist of faculty and technical staff.
- ProfessorAtsushi Yamaguchi
- Assistant ProfessorMasaki Yoshioka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “White Matter Connections Obtained with MRI Tractography” Xavier Gigandet et. al. / CC BY 2.5 (cropped)
- Analysis of Fiber Tract Networks: “DTI-sagittal-fibers” Thomas Schultz / CC BY-SA 3.0 (cropped)
- Pathology of Cerebral Infarction: “Kortikaler Infarkt mit Schrankenstoerung” Hellerhoff / CC BY-SA 3.0 (cropped)
- Onset Mechanisms of ALS: “Neuron in tissue culture” GerryShaw / CC BY-SA 3.0 (cropped)
- Related lab (発生再生医学): “Mouse MOB three color” Matt Valley / Public domain (cropped)
- Related lab (脳神経外科学): “Эндоскоп (ФЦН Тюмень)” Дмитрий Кошелев / CC BY-SA 3.0 (cropped)
- Related lab (認知
行動生理学): “Brain model 12” John Campbell / CC BY 2.0 (cropped) - Related lab (精神神経科学): “Neuroscience 2” Priit Tiganik / CC BY-SA 3.0 (cropped)
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