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Gastrointestinal Surgery Lab
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A surgery lab that explores the diagnosis and treatment of gastrointestinal cancer using glycans (sugar chains) as clues.
AboutAbout the lab
Honing a surgeon's skills while also pursuing reproducibility.
The Gastrointestinal Surgery Lab conducts research with the dream of an era in which patients with gastrointestinal cancer no longer suffer, and an era in which diseases for which organ transplantation has meant giving up can be cured.
Doing experiments while performing surgery can be a trial, but the lab regards its greatest advantage as an environment where members can collect fresh clinical specimens themselves and study them themselves.
In collaboration with institutions such as the National Institute of Advanced Industrial Science and Technology (AIST), also in Tsukuba, the lab conducts basic cancer research using glycan analysis technology.
Medical students are also welcome to observe and take part in surgery and clinical care as practical training.
Key terms
- Glycan (sugar chain)
- A coating, like a garment, that covers the surface of all cells, including cancer cells. Analysis techniques are used to examine its structure.
- Lectin
- A protein that binds to sugars. Used in research on treatments that target glycans on the surface of cancer cells.
- Organoid
- A model made from a patient's tumor or normal tissue that takes a form close to actual cancer or normal tissue.
- Exosome
- A membrane vesicle about 50 to 150 nm in diameter, secreted by all kinds of cells. Found in body fluids, it carries information between cells.
ResearchResearch themes
Aiming for an era in which patients with gastrointestinal cancer no longer suffer, the lab conducts basic cancer research using fresh clinical specimens. In collaboration with AIST and others, it applies glycan analysis technology to develop therapeutic drugs, diagnostic methods, and models that closely resemble individual patients' tumors.
*Illustrative imageCancer therapeutics targeting glycans
In joint work with the Drug Discovery Platform Research Division at AIST, the lab studies treatments that target glycans on the surface of cancer cells using lectins, proteins that bind to sugars. Lectin-drug conjugates showed higher anticancer activity than conventional antibody-drug conjugates.
*Illustrative imageCreating patient-derived organoids
Using tumor and normal tissue taken from patients, the lab creates models (organoids) that take a form close to actual cancer and normal tissue. They are expected to be applied to drug efficacy testing and drug discovery research while reducing the use of animals.
*Illustrative imageDetecting cancer-derived glycoproteins
Using antibodies and lectins, the lab is developing a kit to detect glycoproteins derived from pancreatic cancer. In experiments using serum from pancreatic cancer patients, it has succeeded in detecting substances derived from pancreatic cancer.
*Illustrative imageGlycan analysis of exosomes
Focusing on the glycans covering the surface of exosomes, the lab analyzes the glycans of exosomes in cancer cell culture supernatant and in patients' body fluids, aiming to apply this to cancer diagnosis. In pancreatic cancer cell lines, it has shown that the glycan structures of the exosomes and of the cells themselves are almost the same.
MembersFaculty
The members of the Gastrointestinal Surgery Lab consist of faculty, hospital faculty, visiting researchers, doctoral students and residents, and secretaries.
- ProfessorTatsuya Oda
- Associate ProfessorYoshimasa Akashi
- LecturerKazuhiro Takahashi
- LecturerYohei Owada
- LecturerKinji Furuya
- LecturerDaichi Kitaguchi
- LecturerYoshihiro Miayazaki
- LecturerTsunehiko Maruyama
- LecturerTomoaki Furuta
- LecturerHiromitsu Nakahashi
- Hospital LecturerShuntaro Tsukamoto
- Project Associate ProfessorKoichi Ogawa
- Project Associate ProfessorOsamu Shimomura
- LecturerKen Nakayama
- ProfessorShinji Shinji
- Associate ProfessorYusuke Ohara
- ProfessorKatsuji Hisakura
- Assistant ProfessorJaejeong Kim
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Kinyoun's laboratory” Unknown photographer / Public domain (cropped)
- Cancer therapeutics targeting glycans: “Concanavalin A vs Lectin” Andreas Prlic / CC BY-SA 3.0 (cropped)
- Creating patient-derived organoids: “Flask incubator shaker” Diane A. Reid (Photographer) / Public domain (cropped)
- Detecting cancer-derived glycoproteins: “HIV and Syphilis Diagnostics Laboratory Workstation” Aliva Sahoo / CC BY 4.0 (cropped)
- Glycan analysis of exosomes: “Beckman-Coulter ultracentrifuge XL-100K 02” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
- Related lab (Hematology Lab): “Eosinophil blood smear” Bobjgalindo / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Immunotherapy Research Lab): “Laminaar TYKI DL20221105” Darja.Lavogina / CC BY-SA 4.0 (cropped)
- Related lab (Emergency and Critical Care Medicine Lab): “Bruce Woodbury Beltway Medical Incident 5” Noah Wulf / CC BY-SA 4.0 (cropped)
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