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Hematology Lab
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The Hematology Lab explores hematologic cancers and the “niche” formed with the microenvironment through genomic and single-cell analysis.
AboutAbout the lab
Unraveling the “niche” formed by cancer cells and their microenvironment
The Hematology Lab studies the mechanisms underlying hematologic cancers such as malignant lymphoma, as well as diseases that arise with aging.
Believing that cancer cells are shaped through their interactions with the surrounding microenvironment, the lab investigates them by combining single-cell analysis, spatial omics analysis, and genomic analysis.
The lab is attached to a clinical department, and by analyzing patient cohorts, it aims to develop new diagnostics and treatments as well as prevention and preemptive medicine.
Lab visits are accepted at any time.
Key terms
- Clonal hematopoiesis
- A phenomenon in which blood clones carrying mutations that arose in hematopoietic stem cells increase with aging
- Microenvironment
- The collection of immune cells, blood vessels, stromal cells, and other components surrounding cancer cells
- Spatial omics analysis
- Analysis that examines gene activity and more within tissue, including positional information in addition to cell types
NewsLab news
A paper by Project Lecturer Suma and colleagues was published in Nature Communications
A paper by Assistant Professor Fujisawa and colleagues was published in Blood
A doctoral student was selected for an outstanding presentation at the 66th Meeting of the Japanese Society for Lymphoma
A paper by Lecturer Suehara and colleagues was published in Leukemia
A paper by Project Lecturer Suma and colleagues was published in Leukemia
ResearchResearch themes
Under the themes of hematologic cancers and the breakdown of immunity and inflammation, the lab seeks to understand the structure and function of the “niche” formed by cancer cells and their microenvironment, and to uncover the principles by which cancers and age-related diseases arise. Building on these findings, it aims to develop new diagnostics and treatments and to extend them to prevention and preemptive medicine.
*Illustrative imageMalignant Lymphoma and the Microenvironment
Viewing malignant lymphoma as an ecosystem in which cancer cells and the microenvironment form a network, the lab integrates genomic analysis, single-cell analysis, and spatial omics analysis to elucidate the principles of how it is formed.
*Illustrative imageClonal Hematopoiesis and Age-Related Diseases
Using large-scale cohort analysis and preclinical models, the lab investigates how clonal hematopoiesis, in which blood clones expand with aging, alters the immune and inflammatory environment and contributes to disease onset and cancer progression.
*Illustrative imageSpatial Omics and Single-Cell Analysis
The lab integrates single-cell and spatial transcriptome analysis with multiplexed tissue imaging to examine the spatial networks formed by cells in diseased tissue. By understanding even positional information and interactions, it aims to create diagnostics and treatments that target the “niche.”
MembersFaculty
The members of the Hematology Lab consist of faculty, researchers, residents, doctoral, master's, and undergraduate medical students, technical staff and secretaries, and laboratory assistants.As of 2026
- ProfessorMamiko Sakata-Yanagimoto-Yanagimoto
- Lecturer, Clinical ProfessorNaoki Kurita
- LecturerTakayasu Kato
- LecturerTatsuhiro Sakamoto
- LecturerKeiichiro Hattori
- LecturerYasuhito Suehara
- Assistant ProfessorManabu Fujisawa
- Hospital LecturerYusuke Seiki
- Project LecturerSakurako Suma
- Hospital LecturerKenichi Makishima
- Hospital Assistant ProfessorFumiaki Matsumura
- Project Assistant ProfessorNguyen Thi Minh Yen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Eosinophil blood smear” Bobjgalindo / CC BY-SA 4.0 (cropped)
- Malignant Lymphoma and the Microenvironment: “Histopathology of a reactive lymph node in cholecystitis” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Clonal Hematopoiesis and Age-Related Diseases: “Myeloblast” El*Falaf / CC BY-SA 4.0 (cropped)
- Spatial Omics and Single-Cell Analysis: “Fluidigm C1 Single-Cell Auto Prep system” Konrad Förstner / CC BY 2.0 (cropped)
- Related lab (腎臓内科学): “Hemodialysis equipment” U3061292 / CC BY-SA 3.0 (cropped)
- Related lab (神経内科学): “Automated confocal image reader” Neil Emans IPK / CC BY-SA 3.0 (cropped)
- Related lab (微生物叢生態学
（メタボロゲノミクス分野） ): “Anaerobic chamber ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped) - Related lab (ケミカルバイオロジー・IT創薬): “CSIRO ScienceImage 2589 Shape of Protein Backbone” division, CSIRO / CC BY 3.0 (cropped)
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