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Genome Biology Lab
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A lab that investigates disease mechanisms through the genomes and epigenomes of minute clinical specimens.
AboutAbout the lab
Reading disease mechanisms from minute clinical specimens.
The Genome Biology Lab directly analyzes tissue specimens donated by patients, conducting research aimed at elucidating the mechanisms of human diseases and developing therapeutics.
The lab has established techniques that enable genomic analysis even of tissue fragments so small that they can barely be seen under a microscope.
It uses mouse models for technology development, and applies the experience gained from analyzing them to interpreting data from clinical specimens.
Space life science research with JAXA, which has a base in Tsukuba Science City, is also one of the important research areas the lab works on.
Key terms
- Genomics analysis
- Analysis that examines the genetic information (genome) of an organism across its entirety.
- Epigenome
- Information such as marks that regulate how genes function, rather than the DNA sequence itself.
- Biobank
- A facility that manages tissue and other material left over after diagnosis for use in research.
NewsLab news
View More ↗ResearchResearch themes
The lab studies human diseases directly using tissue specimens donated by patients rather than cultured cells, aiming to elucidate disease mechanisms and develop therapeutics. Mouse models are used to develop genome and epigenome analysis technologies, which are also applied to JAXA's space life science research and other work.
Genome and epigenome analysis of minute clinical specimens
In collaboration with the Tsukuba Human Tissue Biobank Center and the pathological diagnosis group, among others, the lab directly analyzes tissue specimens donated by patients. From small tissue fragments, it examines the activity of individual cells within pathological tissue.
*Illustrative imageTechnology development using mouse models
Mouse models are important in developing genomics technologies, and they sometimes yield improvements to existing analyses or ideas for new ones. Because mice are genetically homogeneous and can be raised under identical conditions, errors in the data can be examined.
*Illustrative imageSpace life science
Through collaborative research, the lab is in charge of analyzing various species, including clinical studies of astronauts conducted on the International Space Station and studies of mice raised in space.
MembersFaculty
The Genome Biology Lab consists of faculty members and doctoral and master's students.
- ProfessorMasafumi Muratani
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tissue processing - Solid paraffin block is mounted on the tissue holder of a microtome” Ed Uthman / CC BY-SA 2.0 (cropped)
- Technology development using mouse models: “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Space life science: “Destiny ISS module taken by STS-108” NASA / Public domain (cropped)
- Related lab (Radiation Biology Lab): “Nuclear reactor at TINT” Azitc / CC BY-SA 4.0 (cropped)
- Related lab (Gastrointestinal Surgery Lab): “Kinyoun's laboratory” Unknown photographer / Public domain (cropped)
- Related lab (Laboratory Animal Science Lab): “LRDT Microscopy Micromanipulation” 作者不詳 / Public domain (cropped)
- Related lab (Dermatology Lab): “Dermatoscopy Nevus Reticular” Philipp Tschandl / CC BY-SA 4.0 (cropped)
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