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Molecular Environmental Physiology Lab
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The lab explores biological defense, focusing on oxidative stress and p62.
AboutAbout the lab
Exploring how the body protects itself, with p62 as a clue.
The Molecular Environmental Physiology Lab does research in environmental physiology and pathological biochemistry, with oxidative stress and biological defense as its research keywords.
Focusing on p62, a selective substrate of autophagy, the lab investigates how its localization inside cells is controlled, how it moves, and what it does.
Functional analysis of genes that respond to oxidative stress is also an ongoing research theme.
What kinds of disease conditions abnormalities in p62 cause is also a subject of study.
Key terms
- Autophagy
- A mechanism by which cells break down and process their own components. p62 is a molecule involved in its selective degradation.
- p62
- A protein that functions as a selective substrate and adapter molecule in autophagy. It is also called SQSTM1.
- Oxidative stress
- A state in which oxidation reactions become excessive inside cells and place a burden on the body. It is one of this lab's research keywords.
ResearchResearch themes
With oxidative stress and biological defense as its research keywords, the lab focuses on p62, a selective substrate of autophagy, and on genes that respond to oxidative stress. On p62, it studies its movement and function inside cells and the disease conditions caused by its abnormalities.
*Illustrative imageMovement and Function of p62 Inside Cells
The lab investigates where p62, a selective substrate of autophagy, moves within cells and what functions it performs. The control of its localization and the disease conditions caused by its abnormalities are also studied.
*Illustrative imageFunction of Oxidative Stress Response Genes
Through functional analysis of genes, the lab investigates what roles genes that act in response to oxidative stress play in cells and in the body.
MembersFaculty
- Associate ProfessorEiji Warabi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PonceauMembrane” Argymeg / CC BY-SA 3.0 (cropped)
- Movement and Function of p62 Inside Cells: “Fluorescence.microscope2” Bioguy10 / CC0 (cropped)
- Function of Oxidative Stress Response Genes: “Molecular biology problem” Williw2 / CC0 (cropped)
- Related lab (分子細胞生物学): “Yeast Cells in Wet Mount Microscopy of Culture” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (解剖学・発生学): “Laboratory microcentrifuge tubes and pipette tips 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (免疫学): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (創薬化学
（WPI-IIIS） ): “Fluorenona en matraz esférico” Manuel Almagro Rivas / CC BY-SA 4.0 (cropped)
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