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Immunology Lab
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The lab explores the mechanisms of cancer and allergy through the receptors of immune cells.
AboutAbout the lab
Discovering new immune receptors ahead of the rest of the world.
The Immunology Lab studies the mechanisms of immune responses, using the immune receptors on the surface of immune cells as a clue.
Immune cells exchange information with each other through receptors, activating and suppressing one another to produce an immune response.
The lab was the first in the world to identify new immune receptors such as DNAM-1, and has investigated their involvement in allergy, autoimmune diseases, and carcinogenesis using animal models and other methods.
The lab aims to develop new treatments for intractable diseases, and joint research on some of the receptors is under way with venture companies and pharmaceutical companies.
Key terms
- Immune receptor
- A molecule on the surface of immune cells that mainly handles the exchange of information between immune cells
- NK cell
- An immune cell that directly kills cancer cells and virus-infected cells
- Ligand
- A molecule that binds to a receptor
NewsLab news
Paper from joint research with the Department of Breast, Endocrine and Thyroid Surgery published in Cancer Medicine
Paper by a PhD student published in Biochemical and Biophysical Research Communications
Professor Kazuko Shibuya received the FY2025 (Reiwa 7) Best teacher's award
Paper by Professor Kazuko Shibuya and Professor Akira Shibuya published in Nature Immunology (News and Views)
Paper by a PhD student published in Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
ResearchResearch themes
Abnormalities of the immune system are involved in autoimmune diseases, allergy, cancer, rejection of transplanted organs, and more. The lab analyzes immune receptors it was the first in the world to discover, at levels ranging from genes, molecules, and cells to whole individuals using genetically modified mice and other models, aiming to clarify new basic principles of the immune system.
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MembersFaculty
The members of the Immunology Lab consist of faculty, lecturers and researchers from joint research, PhD and master's students, commissioned researchers, undergraduate students, and a secretary.As of 2026
- ProfessorAkira Shibuya
- ProfessorKazuko Shibuya
- Associate ProfessorChigusa Oda
- Assistant ProfessorLin Yu-Hsien
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- The functions of DNAM-1 (CD226): “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Related lab (Stem Cell Therapy Lab): “Agarplate redbloodcells edit” Bill Branson – (Edited by Fir0002)(Edited by Drhx) / Public domain (cropped)
- Related lab (Gene Regulation Lab): “Centrifuge tubes ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (Molecular Environmental Physiology Lab): “PonceauMembrane” Argymeg / CC BY-SA 3.0 (cropped)
- Related lab (Medicinal Chemistry (WPI-IIIS) Lab): “Fluorenona en matraz esférico” Manuel Almagro Rivas / CC BY-SA 4.0 (cropped)
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