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Laboratory Animal Science Lab
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The lab develops techniques for producing and analyzing genetically modified mice.
AboutAbout the lab
Embryo manipulation and genetic modification
The Laboratory Animal Science Lab carries the motto “Embryo Manipulation and Genetic Modification” and studies the production and analysis of genetically modified mice.
It also develops software to examine the DNA of mice created by genome editing, and works on developmental research such as meiosis and the formation of the three germ layers in early embryos.
The lab website lists its location as the Animal Experiment Building of the Laboratory Animal Resource Center at the University of Tsukuba (the website's information dates from around 2016).
Key terms
- Genome editing
- A technology that modifies genes by cutting or rewriting DNA at targeted locations
- Meiosis
- A special type of cell division, occurring in the cells that give rise to sperm and eggs, in which the number of chromosomes is halved
- Three germ layers
- The three layers formed in the early embryo: the ectoderm, mesoderm, and endoderm. They later give rise to the organs of the body
NewsLab news
View More ↗ResearchResearch themes
The lab modifies mouse genes using embryo manipulation techniques such as genome editing and investigates gene function. Its work includes improving the techniques themselves and developing analysis software, alongside research on the mechanisms of germ cells and early embryos.
*Illustrative imageTechniques for producing genome-edited mice
The lab works on improving methods for creating genetically modified mice by genome editing of fertilized eggs. It works with the direct cKO method, which quickly examines gene function in vivo, and a piggyBac-based platform for introducing genes with high efficiency.
*Illustrative imageSoftware for analyzing genome editing results
The lab develops tools that determine how the DNA of genome-edited animals was rewritten, as well as software for efficiently knocking out multiple genes.
*Illustrative imageHow meiosis begins
The lab studies the mechanism that switches germ cells from mitosis to meiosis. Focusing on the function of the protein Max, it analyzes mice such as those with a conditional deletion of the Max gene.
*Illustrative imageHow the three germ layers form in early embryos
Using ES cells and reporter mice that can visualize all three germ layers at the same time, the lab examines how the three germ layers form in mouse embryos. It also conducts research using genome-edited mice to search for exons important for organ formation.
MembersFaculty
- ProfessorSeiya Mizuno
- Associate ProfessorAyumu Suzuki
- Assistant ProfessorAkihiro Kuno
- Project Assistant ProfessorHayate Suzuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “LRDT Microscopy Micromanipulation” 作者不詳 / Public domain (cropped)
- Techniques for producing genome-edited mice: “CRISPR-Cas9 Editing of the Genome ( )” National Human Genome Research Institute (NHGRI) / CC BY 2.0 (cropped)
- Software for analyzing genome editing results: “Rack of Worldwide LHC Computing Grid” Marián Hubinský / CC BY-SA 4.0 (cropped)
- How meiosis begins: “Chromosome squash from salivary glands of Drosophila melanogaster larvae” Nulu iman / CC BY-SA 4.0 (cropped)
- How the three germ layers form in early embryos: “Microdrop embryo culture dish” S.Y.M.B.I.O.N.T. / CC BY-SA 4.0 (cropped)
- Related lab (Diagnostic Pathology Lab): “Pathologist” Oktay98 / CC BY-SA 4.0 (cropped)
- Related lab (Bioinformatics Lab): “Eppendorf epMotion 5075 liquid handling robot” Magnus Manske / CC BY-SA 3.0 (cropped)
- Related lab (Sleep Physiology Lab (WPI-IIIS)): “Rapid eye movement sleep behavior disorder” Uguccioni G, Pallanca O, Golmard J, Dodet P, Herlin B, Leu-Semenescu S, Arnulf I / CC BY 4.0 (cropped)
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