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Radiation Biology Lab
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A radiation biology lab that studies drugs and combination therapies to enhance the effects of radiation therapy.
AboutAbout the lab
Enhancing the effects of radiation therapy through biology
The Radiation Biology Lab conducts research to enhance the effectiveness of cancer treatment that uses radiation.
It works on boron drugs used in boron neutron capture therapy (BNCT), and on treatments that combine radiation with nanofiber meshes that release drugs gradually.
The lab is also involved in research on models of cell survival in particle therapy combined with hyperthermia.
Key terms
- Boron Neutron Capture Therapy (BNCT)
- A cancer treatment that uses a boron-containing drug and a neutron beam.
- Glioblastoma
- A malignant tumor that arises in the brain; a type of brain tumor.
- Nanofiber mesh
- A mesh-like material made of nano-sized fibers, engineered to release a drug gradually.
NewsLab news
Paper on a model for estimating cell survival in particle hyperthermic radiation therapy published in Physics in Medicine and Biology
Paper on the preclinical validation of the iBNCT001 accelerator system for BNCT published in Applied Sciences
Paper on an update of the adverse event profile of accelerator-based BNCT published in Journal of Cancer Research and Therapeutics
Paper on a biophysical model of cell survival in particle therapy combined with hyperthermia published in Physics in Medicine and Biology
Yoshitaka Matsumoto received the Excellent Presentation Award at the 21st Ibaraki Radiation Oncology Research Meeting
ResearchResearch themes
Aiming to enhance the effectiveness of cancer treatment that uses radiation, the lab studies boron drugs, nanofiber meshes that release drugs, and combination with hyperthermia. It also conducts research validating the accelerator system used for BNCT, including cell-based confirmation of its effects and evaluation of beam quality.
*Illustrative imageDrug-Releasing Nanofiber Mesh
The lab is developing a treatment for glioblastoma that combines radiation with a nanofiber mesh that releases a drug gradually. It also studies a method of using hyperthermia as a trigger to release the drug from the mesh.
*Illustrative imageSupramolecular Boron Formulation for BNCT
The lab is investigating the antitumor effect of a supramolecular formulation containing phenylboronic acid (FPBA-PRX) as a boron drug for BNCT. It explores ways to deliver the drug efficiently and enhance the therapeutic effect.
*Illustrative imageBNCT Efficacy and Drug Accumulation
In head and neck squamous cell carcinoma, the lab analyzes the therapeutic effect of BNCT and the amino acid transporters associated with accumulation of the boron drug BPA. It also examines the relationship with how readily BPA accumulates inside cells.
*Illustrative imageParticle Therapy Combined with Hyperthermia and Cell Survival
The lab is involved, as an author of the paper, in research on a biophysical model that describes how many cells survive when particle therapy is combined with hyperthermia, based on temperature and radiation quality.
MembersFaculty
- Associate ProfessorYoshitaka Matsumoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nuclear reactor at TINT” Azitc / CC BY-SA 4.0 (cropped)
- Drug-Releasing Nanofiber Mesh: “Electronspun Nanofibers April 2023” Deander4 / CC BY-SA 4.0 (cropped)
- Supramolecular Boron Formulation for BNCT: “Equipment and glassware” Belikov Maxim / CC BY 4.0 (cropped)
- BNCT Efficacy and Drug Accumulation: “Linear Accelerator - Elekta Compact model” Narenfox / CC BY-SA 4.0 (cropped)
- Particle Therapy Combined with Hyperthermia and Cell Survival: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Related lab (Radiation Oncology Lab): “Maximar 100 X-Ray Unit Superficial Therapy” Pairko / CC BY-SA 4.0 (cropped)
- Related lab (Neurosurgery Lab): “Surgical instrument arranged in a theatre” Ibrahim Achiri / CC BY-SA 4.0 (cropped)
- Related lab (Radiation Health Risk Science Lab): “8th CES and 8th MDG maintain nuclear and radiation emergency response readiness (9330024)” U.S. Air Force photo by Senior Airman Karissa Dick / Public domain (cropped)
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