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Regenerative Stem Cell Biology Lab
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A lab working toward regenerative medicine through stem cells and the hypoxic response.
AboutAbout the lab
Unraveling how stem cells and the hypoxic response work.
The Regenerative Stem Cell Biology Lab uses human-derived stem cells to study the mechanisms of cell proliferation and differentiation and how cells respond to hypoxia.
The lab works on the hypoxic response, tissue stem cells, cancer and stem cells, and retinal regeneration for glaucoma.
It aims to apply its findings clinically and contribute to the advancement of regenerative medicine.
The lab's website also introduces it under the name "Ohneda Lab."
Key terms
- HIF
- A transcription factor that escapes degradation and becomes active in low-oxygen environments, rapidly activating the transcription of the genes that are needed.
- Tissue stem cells
- Cells found in every tissue of the body, with the ability to differentiate into multiple cell types and to self-renew.
- Direct reprogramming
- A technique that converts cells directly into another cell type without passing through a pluripotent stem cell stage.
- Retinal ganglion cells
- Cells located in the innermost layer of the retina that form the axons of the optic nerve, which transmits visual information to the brain.
NewsLab news
A student received an Excellence Award for their master's thesis
A student received the Outstanding Scientist Award at the NTU Summer Program (Taiwan)
A student received the Outstanding Poster Presentation Award at the International Joint Symposium on Molecular and Cell Biology
A student's research was published in Frontiers in Cell and Developmental Biology
A student received a Young Investigator Award
ResearchResearch themes
The lab's goal is to use human-derived stem cells to clarify the mechanisms of cell proliferation, differentiation, and response to hypoxia. It aims to apply its findings clinically and contribute to the advancement of regenerative medicine.
*Illustrative imageAnalysis of HIF, a hypoxia-responsive transcription factor
The lab investigates how HIF, a transcription factor that responds to hypoxia, functions as a molecule. Using genetically modified mice, it seeks to clarify how HIF actually acts in vivo.
*Illustrative imageAnalysis of the properties of human tissue stem cells
In collaboration with the orthopedic surgery and cardiovascular surgery departments at the University of Tsukuba, among others, the lab studies the biological characteristics of mesenchymal stem cells and endothelial progenitor cells, as well as the mechanisms of tissue repair. It aims for prompt clinical application of the results.
*Illustrative imageInteractions between cancer cells and stem cells
To cure cancer, it is necessary to understand how cancer cells interact with surrounding cells, including stem cells. Using breast cancer cell lines and human tissue-derived mesenchymal stem cells, the lab studies the interactions between cancer cells and tissue stem cells.
*Illustrative imageRegeneration of retinal ganglion cells for glaucoma
In collaboration with the Advanced Vision Medicine Lab, the lab aims to regenerate retinal ganglion cells, which are damaged in glaucoma, using direct reprogramming, a regenerative medicine technique. With clinical applications in view, it carries out basic experiments day after day.
MembersFaculty
The Regenerative Stem Cell Biology Lab consists of faculty members, postdoctoral researchers, doctoral, master's, and undergraduate students, and technical staff.As of 2025
- ProfessorOsamu Ohneda
- Assistant ProfessorToshiharu Yamashita
- Assistant ProfessorVuong Cat Khanh
- Assistant ProfessorMizuho Fukushige
- Associate ProfessorShinichi Fukuda
- Assistant ProfessorDonny Lukmanto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory Incubator; from a medical laboratory in Abuja, Nigeria” Frankincense Diala / CC0 (cropped)
- Analysis of HIF, a hypoxia-responsive transcription factor: “Advance chamber program” Paulbuza / CC BY-SA 4.0 (cropped)
- Analysis of the properties of human tissue stem cells: “Regenerative medicine” Andrewrgross / CC BY-SA 4.0 (cropped)
- Interactions between cancer cells and stem cells: “Heterogeneous breast tumor in 3D” Sshah74 / CC BY 4.0 (cropped)
- Regeneration of retinal ganglion cells for glaucoma: “Fundus photograph-normal retina EDA06” National Eye Institute, National Institutes of Health / Public domain (cropped)
- Related lab (遺伝子制御学): “Centrifuge tubes ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Related lab (解剖学・発生学): “Laboratory microcentrifuge tubes and pipette tips 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (分子病理学): “Laminar flow hood 2” TimVickers / Public domain (cropped)
- Related lab (幹細胞治療): “Agarplate redbloodcells edit” Bill Branson – (Edited by Fir0002)(Edited by Drhx) / Public domain (cropped)
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