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Genome Function Analysis Lab (Advanced Research Center for Innovations in Next-Generation Medicine)
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A lab that studies the functions of small Maf proteins and also supports genome analysis.
AboutAbout the lab
Genome information determines cell state.
The Genome Function Analysis Lab studies small Maf proteins (sMaf), which play an important role in the transcriptional response of genes to stress.
Genome information encoded in the DNA sequence goes through transcription and translation to determine cell differentiation and homeostasis.
Small Maf proteins form dimers with CNC and Bach proteins and regulate transcription through CsMBE.
The goal of the research is to clarify the molecular basis of this regulation of gene expression.
The lab also works on developing genome analysis methods that use next-generation sequencers.
Key terms
- Small Maf proteins
- Transcription factors of three types: MafF, MafG, and MafK. They form dimers with CNC and Bach proteins
- Dimer
- A complex formed when two proteins bind together
- CsMBE
- CNC-small Maf binding element. A DNA sequence to which CNC-small Maf dimers bind to regulate transcription
- Next-generation sequencer
- An instrument that reads large amounts of DNA nucleotide sequence at once. It is used for genome analysis
ResearchResearch themes
The lab studies the functions of small Maf proteins, which play an important role in the transcriptional response of genes to stress. It also works on developing genome analysis methods that use next-generation sequencers.
*Illustrative imageRegulation of gene expression by small Maf proteins
Small Maf proteins form dimers with CNC and Bach proteins and regulate transcription through CsMBE. How each dimer selects its target genes, and the functional differences among the three types of small Maf proteins, remain unresolved.
*Illustrative imageGenome analysis with next-generation sequencers
The lab works on developing genome analysis methods that use next-generation sequencers. It supports genome analysis projects run by the Tohoku Medical Megabank Organization, as well as clinical sequencing using clinical specimens.
MembersFaculty
- ProfessorFumiki Katsuoka
- Assistant ProfessorTakanori Hidaka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “20251019 Replica DNA double helix model Berlin 01” Flocci Nivis / CC BY 4.0 (cropped)
- Regulation of gene expression by small Maf proteins: “C-Myc-DNA complex” Mark 'AbsturZ' / CC BY-SA 3.0 (cropped)
- Genome analysis with next-generation sequencers: “Next Gen Sequencer (NIH BioArt 386)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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（東北メディカル・メガバンク 機構） ): “Blood test samples” Fumikas Sagisavas / CC0 (cropped) - Related lab (ゲノム基盤形成
（東北メディカル・メガバンク 機構） ): “DNA Visual Representation of Double-Helix” 作者不詳 / Public domain (cropped) - Related lab (小児病態学): “Visit of Stella Kyriakides, European Commissioner, to the Bambino Gesù Children's Hospital - 2024” Elisabetta Villa / European Union, 2024 / EC - Audiovisual Service / CC BY 4.0 (cropped)
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