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Biomarker Discovery Lab (Tohoku Medical Megabank Organization)
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A lab that searches for disease biomarkers using genome information.
AboutAbout the lab
Aiming for personalized medicine through genomes and biomarkers
The Biomarker Discovery Lab searches for genes and biomarkers associated with diseases and drug sensitivity, using biological samples such as blood collected in a large-scale biobank.
Because genomic information obtained from Western populations does not always apply to Japanese people, the lab builds genome reference panels, develops SNP arrays, and searches for alleles associated with disease and drug sensitivity.
In addition to samples from the Medical Megabank, a cohort of healthy individuals, the lab analyzes clinical specimens from people with diseases, working to identify disease-causing genes and discover biomarkers.
By combining genetic information with omics information, the lab works toward personalized medicine that aims to improve disease prevention, diagnostic accuracy, and treatment effectiveness.
Key terms
- Biobank
- A system that collects and stores biological samples such as blood from many people, and makes them available for research
- SNP array
- A test chip used to examine, all at once, single-letter differences in genes (SNPs) that vary from person to person
- Cohort study
- A study that follows a group of people over time to clarify the relationship between physical characteristics and disease
ResearchResearch themes
This lab searches for genes and biomarkers associated with diseases and drug sensitivity, using samples from a large-scale biobank and clinical specimens. It aims to realize personalized medicine by combining genetic information with omics information.
*Illustrative imageBuilding a foundation of genomic information for Japanese people
Because genomic information from Western populations does not always apply to Japanese people, the lab builds genome reference panels. It develops SNP arrays linked to an information platform that consolidates health and medical records, searches for alleles associated with disease and drug sensitivity, and analyzes correlations with traits and diseases in genome cohort studies.
*Illustrative imageAnalysis of clinical specimens and personalized medicine
In addition to the Medical Megabank, a cohort of healthy individuals, the lab analyzes clinical specimens from people with diseases to search for disease-causing genes and biomarkers. With actual clinical sequencing in view, it aims for personalized medicine that combines genetic information with omics information.
MembersFaculty
- ProfessorNobuo Fuse
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Blood test samples” Fumikas Sagisavas / CC0 (cropped)
- Building a foundation of genomic information for Japanese people: “Human genome assembly GRCh38 chromosomes ideogram NCBI” National Center for Biotechnology Information, screenshot by Aarón Mayo / Public domain (cropped)
- Analysis of clinical specimens and personalized medicine: “NABL Accredited Clinical Pathology Laboratory in Kharghar Navi Mumbai Diagnostic Services” Goleisureintl / CC BY 4.0 (cropped)
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