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Transplantation and Regenerative Medicine Lab (Advanced Research Center for Innovations in Next-Generation Medicine)
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The lab aims to develop treatments for diabetes and liver disease through pancreatic islet and hepatocyte transplantation.

AboutAbout the lab
Dreams and possibilities, courage and drive.
The Transplantation and Regenerative Medicine Lab focuses on pancreatic islet transplantation and hepatocyte transplantation as treatments for diabetes and liver disease.
Islet transplantation is a minimally invasive cell therapy in which the pancreatic islets, which regulate blood glucose, are isolated from the pancreas and transplanted into the liver in a manner similar to an intravenous drip.
The lab aims to establish a curative therapy for severe diabetes, including type 1 diabetes, which was previously considered incurable.
Together with the staff who carry out clinical islet transplantation, the lab conducts translational research that bridges basic research and clinical practice.
Key terms
- Pancreatic islets
- The parts of the pancreas that play an important role in regulating blood glucose. In islet transplantation, they are isolated from the pancreas and used
- Minimally invasive
- Reducing the burden on the body as much as possible in surgery and other treatments. Islet transplantation is performed in a manner similar to an intravenous drip
- Type 1 diabetes
- A form of diabetes in which the insulin-producing cells in the pancreatic islets are destroyed, leaving too little of the hormone that lowers blood glucose
NewsLab news
A student received the Gold Award at the 37th Annual Meeting of the Japan Society of Endocrine Surgery
A student received the Excellence Prize of the Shinyu Outstanding Student Award for FY2023
ResearchResearch themes
This lab focuses its research on pancreatic islet transplantation and hepatocyte transplantation for diabetes and liver disease. Building on surgical research, it draws on knowledge from engineering, pharmacy, agriculture, molecular biology, immunology, and other fields to investigate clinically relevant problems across disciplinary boundaries.
*Illustrative imageSolving the challenges of islet transplantation
The lab addresses challenges in islet transplantation, such as long-term outcomes and the need for organs from multiple donors to treat a single patient. Its results on islet isolation techniques and evaluation methods are already used in actual transplantation practice.
*Illustrative imageEstablishing hepatocyte transplantation
The lab applies the various methods it has developed for islet transplantation, with the aim of establishing hepatocyte transplantation as a medical treatment. Together with islet transplantation, it forms the cell transplantation research that is the core of the lab.
MembersFaculty
- ProfessorMasafumi Goto
- Assistant ProfessorAkiko Inagaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell metabolism and color” Zhiguo.he / CC BY-SA 4.0 (cropped)
- Solving the challenges of islet transplantation: “Centrifuge in Laboratory 1” Ivangiesen / CC0 (cropped)
- Establishing hepatocyte transplantation: “Line of culture flask ( )” Jean-Etienne Minh-Duy Poirrier from USA / CC BY-SA 2.0 (cropped)
- Related lab (Environmental Medicine Lab): “Disposable Pipette Tips in Laboratory Tip Boxes 02” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Precision Ophthalmic Medicine Development Lab (Affiliated Center for Innovative Applied Medicine)): “Consultation des yeux A l'hôpital Laquintinie de Douala 16” Destiny Deffo / CC BY-SA 4.0 (cropped)
- Related lab (Gastroenterology Lab): “Endoscopy room” Gilo1969 / CC BY 2.0 (cropped)
- Related lab (Gastroenterological Surgery Lab): “Laparoscopic Hand Instruments 001 JPN” ignis / CC BY-SA 3.0 (cropped)
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