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Environmental Medicine Lab
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A lab that explores the relationship between the environment and health through ferroptosis, a form of cell death.
AboutAbout the lab
Uncovering cell death driven by iron, oxygen, and lipids
The Division of Environmental Medicine is a lab that investigates, from molecules to whole organisms, how the environment affects human health and disease.
Its main keywords are ferroptosis, a form of cell death, redox regulation, oxidative stress, and drug discovery applications.
Ferroptosis is a cell death that arises from the dual nature of iron, oxygen, and lipids. In cancer, inducing it is expected to serve as a treatment strategy, while in conditions such as organ injury, suppressing it may lead to treatment.
This long-established division originated from the Department of Hygiene at Tohoku University, and Professor Eikan Mishima joined it in April 2026.
Key terms
- Ferroptosis
- A form of cell death caused by iron-dependent oxidation of lipids
- Redox
- Oxidation and reduction reactions in which substances exchange electrons. They are related to the conditions inside cells
- Oxidative stress
- A state in which oxidation is enhanced in the body and places a burden on cells
NewsLab news
Associate Professor Sato received the Excellent Presentation Award (Poster Category) at the 14th Annual Meeting of the Japanese Society for DOHaD
Graduate school application guidelines updated, with information for graduates of faculties other than medicine
Paper by Associate Professor Ito and colleagues published in Free radical biology & medicine
Associate Professor Ito received the 2026 UJA Paper Award and Encouragement Award
Paper by Associate Professor Ito and colleagues published in Toxicology
ResearchResearch themes
The lab aims to clarify in an integrated way, from the molecular level to the level of the whole organism, how the environment affects human health and disease, and to return the results to medicine and healthcare. Its research centers on ferroptosis, a form of cell death, investigating its regulatory mechanisms and applications to treatment and drug discovery.
*Illustrative imageRegulation of ferroptosis and its involvement in disease
The lab aims to clarify how ferroptosis is regulated and how it is involved in various disease conditions. Examples of research previously published by Professor Mishima and colleagues include the discovery of the vitamin K and FSP1 pathway, and the intracellular transport of selenium by PRDX6.
*Illustrative imageTreatment and drug discovery targeting ferroptosis
The lab advances treatments and drug discovery that target ferroptosis. Past published examples by Professor Mishima and colleagues include a new system for evaluating the enzymatic activity of GPX4, and the regulation of ferroptosis in cancer through FSP1 inhibition by DHODH inhibitors.
*Illustrative imageExploring unknown redox-related cell death
The lab searches for new redox-related forms of cell death. For modes of cell death that have not yet been identified, it seeks to determine their physiological significance and their potential for application in treatment.
MembersFaculty
The members of the Division of Environmental Medicine are faculty, affiliated faculty, graduate students, undergraduate students, and administrative assistants. Faculty from the Graduate School of Agricultural Science and the Graduate School of Pharmaceutical Sciences also join as affiliated faculty to provide supervision.As of 2026
- ProfessorEikan Mishima
- LecturerMasanobu Morita
- Assistant ProfessorHiroki Taguchi
- Associate ProfessorJunya Ito
- Associate ProfessorEmiko Sato
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Disposable Pipette Tips in Laboratory Tip Boxes 02” Gannu03 / CC BY-SA 4.0 (cropped)
- Regulation of ferroptosis and its involvement in disease: “Lipid peroxidation-it” Tim Vickers, vectorized by Fvasconcellos, translation by Trixt / Public domain (cropped)
- Treatment and drug discovery targeting ferroptosis: “Elektrof” Stefan Walkowski / CC BY-SA 4.0 (cropped)
- Exploring unknown redox-related cell death: “Equipment and glassware” Belikov Maxim / CC BY 4.0 (cropped)
- Related lab (Medical Biochemistry Lab): “Pipette de laboratoire sur fond blanc au Bénin 03” Adoscam / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Medical Biochemistry Lab): “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Oxygen Medicine Lab (Affiliated Center for Innovative Applied Medicine)): “In the Biochemistry Laboratory” Tristan Ferne from UK / CC BY 2.0 (cropped)
- Related lab (Biochemistry Lab): “Rotor for microtubes of an Eppendorf Centrifuge 5430” Karbohut / CC BY-SA 4.0 (cropped)
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