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Gastroenterology Lab
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A lab that studies gastrointestinal diseases broadly, from basic research to clinical research.
AboutAbout the lab
Leading future-oriented medicine in gastroenterology
The Gastroenterology Lab is a division of the Tohoku University Graduate School of Medicine and carries out research on gastrointestinal diseases broadly, from basic research to clinical research.
The lab is divided into groups that each handle diseases of one organ: the upper gastrointestinal tract, the lower gastrointestinal tract, the pancreas, and the liver.
In the professor's greeting, clinical care, research, and education are described as an indispensable trinity, and the lab aims to bring research results back into patient care.
Many residents in specialty training and graduate students are active on the front lines of research and clinical care.
Key terms
- Oxidative stress
- A state in which reactive oxygen species and similar molecules produced in the body damage cells
- Gastroesophageal reflux disease (GERD)
- A disease in which stomach acid flows back into the esophagus and causes symptoms such as heartburn
- Barrett's esophagus
- A condition in which the lining of the esophagus has changed; it is linked to the risk of developing esophageal adenocarcinoma
- Multicenter collaborative study
- A clinical study in which multiple hospitals cooperate under the same protocol and collect cases
NewsLab news
A nationwide epidemiological survey of chronic pancreatitis by Professor Atsushi Masamune and colleagues was published in Journal of Gastroenterology
A study of an ERCP/EST dry simulator by Assistant Professor Yu Hatayama and colleagues was published in DEN Open
A protocol paper for a clinical study of metal stents for Crohn's disease strictures, by Lecturer Rintaro Moroi and colleagues, was published in The Kurume Medical Journal
Associate Professor Atsushi Inoue received the Selected Entry Award at the Roche Infectious Disease Award 2025
A paper on pancreatic cancer cells and type I collagen by students in the basic research training program was published in Tohoku Journal of Experimental Medicine
ResearchResearch themes
The lab works broadly from basic research to clinical research and aims to bring the results back into patient care. The research page lists the research of each group in the order of upper gastrointestinal tract, lower gastrointestinal tract, pancreas, and liver. This page introduces the research of the first group, the upper gastrointestinal group.
*Illustrative imageCarcinogenesis at the Esophagogastric Junction
Using mainly model mice, the lab investigates inflammation-driven carcinogenesis at the esophagogastric junction. It examines the effects of nitric oxide, oxidative stress caused by gastric acid and bile acids, mucus and mucosal bacteria, and interactions with other organs.
*Illustrative imageClinical Research and Device Development for the Upper Gastrointestinal Tract
Focusing on diseases of the upper gastrointestinal tract, the lab leads many nationwide and Tohoku-region multicenter collaborative studies and develops and validates prediction models and decision-support tools useful in clinical practice. It also works on care that takes elderly patients into account, clinical application of AI, and development of medical devices and endoscopic treatment techniques through industry-academia collaboration.
*Illustrative imageGERD and Esophageal Motility
In clinical studies of gastroesophageal reflux disease (GERD) and Barrett's esophagus, the lab uses 24-hour pH-impedance monitoring and esophageal motility testing to evaluate acid reflux and esophageal motion in detail. Its goals are higher diagnostic accuracy, the development of new treatments, and personalized medicine.
*Illustrative imageDeveloping Simulators for Endoscopic Treatment
Through industry-academia collaboration, the lab develops its own highly reproducible simulators for hemostasis in the gastrointestinal tract, endoscopic treatment of early-stage cancer, and biliary and pancreatic endoscopic treatment. In parallel with development, it also conducts educational research that evaluates learning effects.
MembersFaculty
The lab's members consist of professors, associate professors, lecturers, hospital lecturers, assistant professors, medical staff, graduate students, international students, and residents in specialty training, and faculty from other departments also take part in supervision.As of 2026
- ProfessorAtsushi Masamune
- Associate ProfessorTomoyuki Koike
- Associate ProfessorYoichi Kakuta
- LecturerKaname Uno
- LecturerShin Hamada
- LecturerWaku Hatta
- LecturerRintaro Moroi
- Hospital Lecturer (Assistant Professor)Masashi Ninomiya
- Hospital Lecturer (Assistant Professor)Tetsuya Takikawa
- Hospital Lecturer (Assistant Professor)Masahiro Saito
- Hospital Lecturer (Assistant Professor)Takeo Naito
- Assistant ProfessorSusumu Miura
- Assistant ProfessorYu Tanaka
- Assistant ProfessorYusuke Shimoyama
- Assistant ProfessorDaisuke Okamoto
- Assistant ProfessorTakanori Sano
- Assistant ProfessorYu Hatayama
- Assistant ProfessorMizuki Tanabe
- ProfessorAkira Imatani
- Associate ProfessorAtsushi Inoue
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Endoscopy room” Gilo1969 / CC BY 2.0 (cropped)
- Carcinogenesis at the Esophagogastric Junction: “Digestive system diagram mn” derivative work Elvonudinium / CC BY-SA 3.0 (cropped)
- Clinical Research and Device Development for the Upper Gastrointestinal Tract: “Radiologist interpreting MRI” The Medical Futurist editors. / CC BY 4.0 (cropped)
- GERD and Esophageal Motility: “Catheter-9-Port-Esophageal-2617” Gastro-en / Public domain (cropped)
- Developing Simulators for Endoscopic Treatment: “U S , NATO, partner nations participate in Bulgarian Multilateral Medical Simulation Training Engagement (8900662)” U.S. Air Force photo by Airman 1st Class Dylan Myers / Public domain (cropped)
- Related lab (Gastroenterological Surgery Lab): “Laparoscopic Hand Instruments 001 JPN” ignis / CC BY-SA 3.0 (cropped)
- Related lab (Clinical Pharmacy Lab (Graduate School of Pharmaceutical Sciences)): “Tablet packets in exposition History of making of drugs in Kuks Hospital in Kuks, Trutnov District” Jiří Sedláček / CC BY-SA 4.0 (cropped)
- Related lab (Neurology Lab): “PET MRI Scanner (NIH BioArt )” Courtesy of NIAID Malcolm Houston / Public domain (cropped)
- Related lab (Cardiovascular Medicine Lab): “A cardiac catheterization procedure in the Naval Medical Center San Diego hospital’s cardiac catheterization laboratory” Navy Medicine / Public domain (cropped)
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