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Redox Molecular Medicine Lab
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The lab explores the mechanisms of life and disease through supersulfides.
AboutAbout the lab
Decoding the mechanisms of life through supersulfides
The lab studies how the balance between oxidation and reduction in the body (redox) is involved in biological functions and disease.
It focuses in particular on supersulfides, such as cysteine persulfide and polysulfides.
The lab investigates the chemistry of supersulfides, how they are formed in the body, their metabolic network, and their relationship to disease together.
Through this research, the lab aims to open up a new research field in redox medicine.
Key terms
- redox
- Oxidation and reduction reactions. In the body, the balance between the production and elimination of reactive oxygen species is precisely maintained
- reactive oxygen species
- Molecules formed as a result of oxygen use. They damage cells but also act as signaling molecules that regulate cell functions
- supersulfides
- A collective term for molecules such as cysteine persulfide and polysulfides. They are bioactive molecules widely present in the body
- supersulfidomics
- An analytical method, based on mass spectrometry, that comprehensively examines supersulfides in the body
NewsLab news
A research fellow won the Excellent Poster Award at the 4th G-ReXS international conference
An Assistant Professor and an undergraduate student won the Young Investigator Excellent Presentation Award at the Molecular Preventive and Environmental Medicine research conference
A joint research project on supersulfides was launched with Murakami Farm
Prof. Akaike won the 75th Kahoku Culture Award
A Lecturer won the Ishida-Ebina Memorial Hokuto Medical Award at the Tohoku Branch meeting of the Japanese Society for Bacteriology
ResearchResearch themes
Organisms use oxygen to obtain energy efficiently, but this also produces reactive oxygen species. The lab studies redox mechanisms at the molecular level, covering not only reactive oxygen species but also reactive nitrogen species and reactive sulfur species, with a focus on supersulfides.
*Illustrative imageChemistry of Supersulfides
Sulfur can link multiple atoms together, and sulfur metabolites such as persulfides are formed in the body. The lab calls these highly reactive molecules "supersulfides" and studies their chemical properties and physiological functions.
*Illustrative imageComprehensive Analysis of Supersulfide Metabolism
Supersulfides are highly reactive and unstable, and quantifying them in the body had long been difficult. Using original analytical technology based on mass spectrometry, the lab has established "supersulfidomics," a comprehensive analysis of supersulfides in the body.
*Illustrative imageMechanisms of Supersulfide Production
It has become clear that supersulfides are produced by enzymes in the body. The lab studies the reaction mechanisms by which enzymes such as aminoacyl-tRNA synthetases produce persulfides and polysulfides from cysteine.
*Illustrative imageSulfur Respiration in Mammals
In microorganisms, sulfur respiration, which uses sulfur compounds, is well known. It has been suggested that supersulfides may also be involved in electron transfer in mammalian cells. The lab studies their function in mitochondria and aims to establish the concept of sulfur respiration.
MembersFaculty
The lab's members are faculty, research fellows, part-time lecturers, visiting researchers, doctoral and undergraduate students, and administrative assistants.As of 2026
- International Distinguished ProfessorTakaaki Akaike
- ProfessorMieko Arisawa
- Project ProfessorTomoaki Ida
- Project ProfessorTetsuro Matsunaga
- International Distinguished ProfessorUladzimir Barayeu
- LecturerMasanobu Morita
- LecturerTsuyoshi Takata
- Assistant ProfessorMinkyung Jung
- Assistant ProfessorJun Yoshitake
- Assistant ProfessorHeekyung Son
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Liquid chromatograph with mass spectrometer, in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Chemistry of Supersulfides: “Sulfur crystals 1” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
- Comprehensive Analysis of Supersulfide Metabolism: “LC MS pic” US gov / Public domain (cropped)
- Mechanisms of Supersulfide Production: “Suramin ball-and-stick 2H9T” Fvasconcellos / Public domain (cropped)
- Sulfur Respiration in Mammals: “Microbiology practical” M Joko Apriyo Putro / CC BY-SA 4.0 (cropped)
- Related lab (Microbiology Lab): “Colorized transmission electron micrograph of rabies virus particles (green) image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland - 9” NIAID / CC BY 2.0 (cropped)
- Related lab (Medical Zoology Lab): “Lab mice 436262” Understanding Animal Research / CC BY 2.0 (cropped)
- Related lab (Environmental Medicine Lab): “Disposable Pipette Tips in Laboratory Tip Boxes 02” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Disaster Infectious Diseases Lab (International Research Institute of Disaster Science)): “Airmen conduct emergency medical response exercise (8750214)” U.S. Air Force 380AEW by Senior Airman Sir Wyrick / Public domain (cropped)
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