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Medical Zoology Lab
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The lab studies protein function using genetically modified animals.
AboutAbout the lab
Exploring the roles of proteins in genetically modified animals
The Medical Zoology Lab creates and analyzes genetically modified animals to study, at the level of the whole organism, the roles of the proteins encoded by the modified genes.
The lab is located in the Institute for Animal Experimentation attached to the Graduate School of Medicine.
The lab has shown that USP2, which regulates protein ubiquitination, acts as a key molecule in energy metabolism in a variety of organs and influences the progression of lifestyle-related diseases.
By comparing and combining its work with alternatives to animal testing, the lab also aims to develop new research and evaluation approaches that help advance the 3Rs.
Key terms
- Ubiquitination
- A modification in which a small protein called ubiquitin is attached to a protein. It affects the protein's function and abundance.
- Myeloid cells
- A group of cells involved in the blood and immune system, including macrophages.
- Humanized animals
- Animals in which some of their own cells or genes have been replaced with human ones.
- 3Rs
- A framework for animal experiments that promotes replacing animals, reducing the number used, and refining procedures to lessen suffering (Replacement, Reduction, Refinement).
ResearchResearch themes
The lab creates genetically modified animals and studies, at the level of the whole organism, the functions of the proteins encoded by the modified genes. It also aims to develop research and evaluation approaches that combine these animals with alternatives to animal testing and help advance the 3Rs.
USP2 and energy metabolism
The lab has shown that USP2, which regulates protein ubiquitination, acts as a key molecule in energy metabolism in a variety of organs and influences the progression of lifestyle-related diseases.
*Illustrative imageUnknown molecules involved in chronic inflammation
Using multi-omics technologies, the lab identified molecules of unknown function expressed in myeloid cells such as macrophages, and is investigating their roles in chronic inflammatory diseases.
*Illustrative imageHumanized animals and alternatives to animal testing
The lab compares and combines disease model animals and humanized animals, in which animal cells or genes are replaced with human ones, with alternatives to animal testing. The aim is to establish new research and evaluation approaches that help advance the 3Rs.
MembersFaculty
- ProfessorHiroshi Kitamura
- LecturerNobuhiko Harada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lab mice 436262” Understanding Animal Research / CC BY 2.0 (cropped)
- Unknown molecules involved in chronic inflammation: “Biosafety Cabinet” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Humanized animals and alternatives to animal testing: “Microphysiological System” Dominic Doyle & Frank Block, Vanderbilt University / Public domain (cropped)
- Related lab (Molecular Metabolism and Physiology Lab): “DNA Double Helix Model - Biotechnology Gallery - BITM - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Molecular Medical Biochemistry Lab): “Biochemistry laboratory MPI-CBG-panorama” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Tumor Biology Lab (Institute of Development, Aging and Cancer)): “Bacterial cell culture on agar plate ( DNA double helix conformation)” Syed Sajidul Islam / CC BY-SA 4.0 (cropped)
- Related lab (Respiratory Medicine Lab): “COR-2-STND-CHEST-LUNGS” Ptrump16 / CC BY-SA 4.0 (cropped)
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