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Gastroenterological Surgery I Lab
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A surgical lab that studies new treatments for gastrointestinal cancers and liver transplantation through both clinical and basic research.
AboutAbout the lab
Practicing the best and most appropriate surgical care through team-based medicine
The lab is a surgical department that treats cancers of the gastrointestinal tract, such as the colon, and of the liver, biliary tract, and pancreas, as well as liver transplantation and surgical diseases in children.
The lab conducts clinical and basic research based on problems and questions that arise in surgical practice.
Its goal is to train “Academic Surgeons,” surgeons who have acquired the ability to solve problems through basic research early in their careers.
The lab hosts clinical clerkships for medical students (the all-department clinical clerkship and the elective clinical clerkship).
Key terms
- Metformin
- An oral diabetes drug. Its anticancer effects and its effects on immunity are attracting attention.
- Perfusion
- Continuously flowing fluid through the blood vessels of an organ. It is used in methods for preserving and repairing organs that have been removed.
- Islet transplantation
- A treatment for type 1 diabetes in which clusters of insulin-producing pancreatic cells (islets) are transplanted.
NewsLab news
Paper by faculty members published in Surg Endosc
Project Assistant Professor Ara received the Best Presentation Award at the Annual Scientific Meeting of the Japan Digital Medicine Society
Paper by Lecturer Watanabe published in Transpl Infect Dis
Paper by a physician of the lab published in Surg Today
ResearchResearch themes
The lab conducts clinical and basic research rooted in problems and questions from surgical practice. It has five research groups: gastrointestinal, hepato-biliary-pancreatic, organ preservation, transplantation, and pediatric.
*Illustrative imageColorectal Cancer and Immunity
The lab examines how immunity around the tumor changes, and how effective treatment is, when metformin, a diabetes drug, is added to preoperative chemoradiotherapy for rectal cancer. It also studies, in mouse and cell experiments, the mechanism by which combined use with aspirin suppresses colorectal cancer.
*Illustrative imageMechanisms of Hepatocellular Carcinoma
Using hepatocellular carcinoma tissue removed during surgery, the lab studies the function of lymphocytes that have infiltrated the tumor and proteins related to the tumor's characteristics. In collaboration with the Pathogenic Microbiology lab, it also studies the relationship between past hepatitis B virus infection and the development of liver cancer.
*Illustrative imagePreserving and Repairing Organs for Transplantation
The lab studies methods for preserving and repairing livers for transplantation outside the body. Using a rat liver perfusion model, in which fluid is circulated through the liver, it examines the optimal pH and temperature for preservation and searches for markers that predict injury after transplantation.
*Illustrative imageTransplantation and Immunity
In islet transplantation, the lab uses mice to test whether immunoregulatory cells generated ex vivo to match the donor can suppress the inflammation that damages transplanted islets.
MembersFaculty
The lab's members consist of faculty, physicians, physicians dedicated to research (research fellows), specialty residents, and transplant coordinators and clinical engineering technologists from the Organ Transplantation Medicine Division. In addition to the faculty, physicians who serve as chief instructors of each clinical group at Hokkaido University Hospital also take part in educating students and resident physicians.As of 2026
- ProfessorAkinobu Taketomi
- LecturerTatsuhiko Kakisaka
- LecturerMasaaki Watanabe
- Project LecturerTadashi Yoshida
- Assistant ProfessorNorio Kawamura
- Project Assistant ProfessorAkihisa Nagatsu
- Project Assistant ProfessorYoh Asahi
- Project Assistant ProfessorMomoko Ara
- Project Assistant ProfessorTakeshi Aiyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “3D printed liver model - tumor” Jan Witowski / CC BY-SA 4.0 (cropped)
- Colorectal Cancer and Immunity: “Adenocarcinoma of the colon-histology” Netha Hussain / CC BY-SA 3.0 (cropped)
- Mechanisms of Hepatocellular Carcinoma: “01064cha” TexasPathologist / CC BY-SA 4.0 (cropped)
- Preserving and Repairing Organs for Transplantation: “Left Liver Transplant” Aphelpsmd / CC BY-SA 4.0 (cropped)
- Transplantation and Immunity: “Islet of Langerhans in Human Pancreas by Phase Contrast ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Related lab (Gastroenterological Surgery II Lab): “Instruments for laparoscopic Hernia Operation” Anpol42 / CC BY-SA 3.0 (cropped)
- Related lab (Immunobiology Lab): “T Regulatory Cells ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Gastroenterology Lab): “Endoscopy” Linda Bartlett / Public domain (cropped)
- Related lab (Hematology Lab): “Red White Blood cells” Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick) / Public domain (cropped)
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