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Hematology Lab
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The lab studies the mechanisms of blood cancers such as leukemia and lymphoma, and develops new treatments for them.
AboutAbout the lab
Passion, challenge, and inspiration in creating cutting-edge medicine!
The Hematology Lab studies blood diseases such as leukemia and lymphoma, and their treatment.
While valuing the care of each individual patient, the lab's mission is to advance clinical and basic research at a level that contributes to the development of medicine worldwide.
Basic research is divided into three groups: leukemia genetics, hematopoietic stem cell transplantation and immunotherapy, and lymphoma.
Students from the Department of Medicine have presented their research at academic conferences and received awards.
Key terms
- GVHD
- Graft-versus-host disease. A complication in which the donor's immune cells in the transplant attack the patient's body
- CAR-T cells
- The patient's own T cells, genetically engineered to carry a mechanism that recognizes cancer cells
- CRISPR/Cas9
- A technology that cuts a targeted gene to disable it. It allows the roles of many genes to be examined at once
NewsLab news
A paper on a molecular pathway that regulates drug sensitivity in T-cell lymphoma was published in Oncogene
A paper on a new combination therapy for T-cell lymphoma was published in Leukemia
A student from the Department of Medicine received an Outstanding Presentation Award at the Japanese Society of Internal Medicine's Kotohajime 2026
A doctoral student received the ASH2025 Abstract Achievement Award
Assistant Professor Siratori received an Excellent Teacher Award (Award for Excellence) from the Department of Medicine, School of Medicine
ResearchResearch themes
To break through the limits of current medicine, the lab focuses on both clinical and basic research. Basic research is divided into three groups, with themes of leukemia genetics, hematopoietic stem cell transplantation and immunotherapy, and lymphoma.
*Illustrative imageLeukemia Genes and Platelets
The lab investigates genetic abnormalities that recur in leukemia. It leads the Hokkaido Leukemia Net, which collects acute leukemia samples from participating institutions, analyzes mutations related to prognosis, and reports the results back to the attending physicians. The lab also studies the gene mutations behind inherited conditions in which platelet counts are abnormally low or high.
*Illustrative imageHematopoietic Stem Cell Transplantation and Immunotherapy
To make allogeneic hematopoietic stem cell transplantation, which can cure leukemia and other diseases, a safer and more effective treatment, the lab conducts research using mouse models and patient samples. It works on clarifying the mechanisms of GVHD and on developing new treatments that strengthen the function of CAR-T cells.
*Illustrative imageTherapeutic Targets in T-Cell Lymphoma
Focusing on T-cell lymphoma, which is difficult to cure, the lab uses CRISPR/Cas9 to comprehensively screen about 20,000 genes in search of molecules that could become targets for new treatments. It aims to apply the results to drug discovery and to overcoming drug resistance.
MembersFaculty
The members of the Hematology Lab include faculty, hospital staff physicians, graduate students, research residents, and international students. The faculty also include physicians affiliated with Hokkaido University Hospital's Infection Control Department and its Division of Laboratory and Transfusion Medicine.As of 2026
- ProfessorTakanori Teshima
- Associate ProfessorDaigo Hashimoto
- ProfessorTomoyuki Endo
- LecturerKaoru Kahata
- LecturerMasao Nakagawa
- LecturerMasahiro Onozawa
- LecturerHideki Goto
- Assistant ProfessorSoichi Siratori
- Assistant ProfessorToshihiro Matsukawa
- Assistant ProfessorTakahide Ara
- Assistant ProfessorYuta Hasegawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Red White Blood cells” Electron Microscopy Facility at The National Cancer Institute at Frederick (NCI-Frederick) / Public domain (cropped)
- Leukemia Genes and Platelets: “Myeloid leukemia” Makysm / CC0 (cropped)
- Hematopoietic Stem Cell Transplantation and Immunotherapy: “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Therapeutic Targets in T-Cell Lymphoma: “Follicular lymphoma, H&E 1” User:Patho / CC BY-SA 3.0 (cropped)
- Related lab (Otolaryngology–Head and Neck Surgery Lab): “Normal Tympanic Membrane Chorda Tympani Nerve Visible” Michael Hawke MD / CC BY 4.0 (cropped)
- Related lab (Respiratory and Circulatory Innovative Research Lab): “CTA Chest With Massive Pulmonary Embolism and Complete Occlusion” Rvahudson / CC BY-SA 4.0 (cropped)
- Related lab (Gastroenterological Surgery I Lab): “3D printed liver model - tumor” Jan Witowski / CC BY-SA 4.0 (cropped)
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