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Immunobiology Lab
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With transplantation and cancer as its themes, the lab aims to understand and control the mechanisms of the immune system.
AboutAbout the lab
Understanding and controlling how immunity works
The Immunobiology Lab studies the immune mechanisms involved in two main themes: transplantation and cancer.
In transplantation, the lab is developing methods to generate, from iPS cells, cells that underlie immune tolerance, aiming to realize safe regenerative medicine.
In cancer, the lab studies how immunity is suppressed around tumors and develops new cancer vaccines.
Recently, it has also taken up research on cell therapy, which uses cells like drugs, and on xenotransplantation using pig organs.
Key terms
- Immune tolerance
- A state in which the immune system does not attack a specific target. In transplantation, it means the graft is not rejected without immunosuppressants.
- Xenotransplantation
- Medical treatment that transplants organs or cells from another species of animal, such as pigs, into humans.
- Macrophage
- An immune cell that takes in and processes foreign substances and dead cells that enter the body. It also regulates the activity of surrounding cells.
NewsLab news
Discovered that iPS cells and ES cells themselves induce transplant immune tolerance (PNAS)
Revealed the therapeutic effect of macrophages induced by IL-34 on liver fibrosis
A doctoral student received the Best Presentation Award at the 53rd Annual Meeting of the Japanese Society for Immunology
ResearchResearch themes
Based on its background in the clinical care of organ transplantation and cancer, the lab studies immunology and related biology centered on two major themes: transplantation and cancer. It works on transplantation using iPS cells, xenotransplantation, and cell therapy using macrophages.
*Illustrative imageTransplantation with iPS cells and immune tolerance
When iPS cells made from another person's cells are transplanted, they are rejected even when the difference is not in HLA. Using a mouse experimental system in which rejection occurs, the lab generates cells from iPS cells that underlie immune tolerance, and aims to induce immune tolerance through cell therapy.
*Illustrative imageXenotransplantation using genetically modified pigs
Organ transplantation faces a shortage of donors, and xenotransplantation using animals as donors is expected to become practical. In collaboration with the Department of Renal and Genitourinary Surgery, the lab aims to realize xenotransplantation using genetically modified pigs in Japan.
*Illustrative imageCell therapy for fibrosis using macrophages
The lab has revealed how immunosuppressive macrophages generated by the cytokine IL-34 weaken immunity against cancer. Making use of these macrophages in the opposite way, it is studying a cell therapy for liver fibrosis in animal experiments.
MembersFaculty
The members of the Immunobiology Lab consist of faculty, visiting professors, doctoral and master's students, collaborative researchers, research support staff, research assistants, and visiting researchers.As of 2026
- ProfessorKen-ichiro Seino
- Assistant ProfessorAkihiro Mori
- Assistant ProfessorTomoki Kamatani
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “T Regulatory Cells ( )” NIAID / CC BY 2.0 (cropped)
- Transplantation with iPS cells and immune tolerance: “Иммуноцитохимическое окрашивание культуры клеток человека” Daria Goliusova / CC BY 4.0 (cropped)
- Xenotransplantation using genetically modified pigs: “Sus scrofa domesticus, miniature pig, juvenile” Johan Spaedtke / CC0 (cropped)
- Cell therapy for fibrosis using macrophages: “Cirrhosis of the liver (trichrome stain) ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Gastroenterological Surgery I Lab): “3D printed liver model - tumor” Jan Witowski / CC BY-SA 4.0 (cropped)
- Related lab (Otolaryngology–Head and Neck Surgery Lab): “Normal Tympanic Membrane Chorda Tympani Nerve Visible” Michael Hawke MD / CC BY 4.0 (cropped)
- Related lab (Neurology Lab): “Neurological tools” Ali Raheem / CC BY-SA 3.0 (cropped)
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