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生命物理化学教室
Showing the original Japanese · View translation
NMRで生体分子の動きをつぶさに見て、創薬に生かす研究室。
AboutAbout the lab
分子の動きから、生命と薬を理解する。
生命物理化学教室は、
核磁気共鳴
タンパク質や
高分子量の
Key terms
- 核磁気共鳴
（NMR） - 強い
磁場の 中で 原子核が 出す信号から、 分子の 形や 動きを 原子レベルで 調べる 方法 - GPCR
- 細胞膜に
あって 外からの 刺激を 細胞の 中へ 伝える 受容体。 多くの 薬の 標的 - リガンド
- タンパク質などの
特定の 場所に 結合する 分子。 薬の 候補に なる
NewsLab news
ヒトの
膜タンパク質の 動きを 高感度に とらえる NMRの 技術を 開発（Journal of the American Chemical Society） RNAの
構造平衡が 阻害剤の 効き方に 影響する ことを 示した 論文が ACS Chem Biolに 掲載 RNAヘリカーゼDDX3Xが
ストレス顆粒を つくる しくみの 一端を 解明 外山特任助教が
文部科学大臣表彰・若手科 学者賞を 受賞 修士課程の
学生が、 第146回日本薬学会で 優秀発表賞を 受賞
ResearchResearch themes
タンパク質などの
*Illustrative image多くの薬に結合するタンパク質
多剤耐性は
*Illustrative imageGPCRが活性化するしくみ
市販薬の
*Illustrative imageシグナル伝達のモデルづくり
NMR法で
*Illustrative image隠れた薬の結合部位を見つける
リガンドが
MembersFaculty
生命物理化学教室の
- Professor竹内 恒Publications ↗
- Lecturer幸福 裕Publications ↗
- Assistant Professor外山 侑樹Publications ↗
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RelatedLabs similar to 生命物理化学教室
The information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “NMR Spectrometer” Mgianino / CC BY 3.0 (cropped)
- 多くの
薬に 結合する タンパク質: “Staphylococcus aureus VISA 2” Content Providers(s): CDC/ Matthew J. Arduino, DRPH Photo Credit: Janice Haney Carr / Public domain (cropped) - GPCRが
活性化する しく み: “XBio illustration – G Protein Coupled Receptor (GPCR)” explorebiology / CC BY 4.0 (cropped) - シグナル伝達の
モデルづくり: “Signal transduction pathways zh” File:Signal transduction pathways.png: Boghog2 at English Wikipedia derivative work: GnolizX / Public domain (cropped) - 隠れた
薬の 結合 部位を 見つける : “The green structures represent the cartoon representation of the protein's alpha-helices, while the grey surface shows the accessible molecular surface of the binding pocket” A / CC BY-SA 4.0 (cropped) - Related lab (遺伝学教室): “Drosophila melanogaster under microscope” Talita Oliveira / CC BY-SA 4.0 (cropped)
- Related lab (生体分析化学教室): “Nikon-Inverted fluorescence microscope” ArthurLau1997 / CC BY 4.0 (cropped)
- Related lab (衛生化学教室): “Applied Biosystems 4000 QTrap Mass Spectrometer (detail) (11)” Hey Paul from Sacramento, CA, USA / CC BY 2.0 (cropped)
- Related lab (基礎有機化学教室): “Benzene IBO” Alicesu / CC BY-SA 4.0 (cropped)
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