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15 labs · 8 student voices
Other departments in Faculty of Pharmaceutical Sciences ›Faculties at The University of Tokyo ›
Shigeo Murata, Professor
Bio & Life Sciences1 student voices
The Protein Metabolism Lab studies how the proteasome, the main protein-degradation machinery inside cells, controls cellular function. The proteasome degrades proteins tagged with ubiquitin and plays an essential role in many biological processes, including the cell cycle and signal transduction. The lab uses a wide range of approaches, including cell biology, biochemistry, mouse genetic engineering, and yeast and Drosophila genetics. The lab aims to elucidate how abnormalities in the amount or activity of the proteasome lead to diseases and conditions such as cancer, neurodegeneration, and aging.
Yuichiro Nakajima, Associate Professor
Bio & Life Sciences1 student voices
The Genetics Lab studies "plasticity of cell fate," the ability of cells to change their properties and roles in response to circumstances. Animal bodies maintain homeostasis while responding to environmental changes such as nutrition, temperature, injury, and inflammation, and plasticity underlies this ability. Plasticity is essential for an organism's adaptation, but it is also thought to be closely linked to chronic inflammation and to functional changes that accompany aging. Through comparative studies using fruit flies (Drosophila) and jellyfish, the lab seeks to uncover the common principles of plasticity in living systems.
Daiju Kitagawa, Professor
Bio & Life Sciences1 student voices
The lab aims to understand the mechanisms of cell division, which proceeds through many stages, and to develop that understanding into drug discovery, including new anticancer drugs. It focuses in particular on centrosome duplication and on how the spindle forms and segregates chromosomes. Centering on the relationship between proteins and non-coding RNAs, the lab combines a wide range of methods, including cell biology, biochemistry, structural biology, and simulation. The lab also reproduces in vitro the interactions between cells that take place in the body, in order to clarify the molecular mechanisms behind them.
Junken Aoki, Professor
Bio & Life Sciences1 student voices
The Health Chemistry Lab studies the functions of lipids and lipid-related molecules at the cellular and whole-organism levels. Biological membranes are made up of more than 1,000 types of lipid molecules, and each one is thought to have its own specific function. Because lipids are not directly encoded by genes, studying their functions is a far more difficult challenge than studying proteins. Using technologies such as mass microscopy and mass spectrometry, the lab works to clarify the functions of a wide variety of phospholipids.
Koh Takeuchi, Professor
Bio & Life Sciences1 student voices
The Biophysical Chemistry Lab studies how the molecules that sustain life move and function. Using physical chemistry methods centered on nuclear magnetic resonance (NMR), the lab observes the dynamic behavior of molecules and seeks to clarify how those molecules contribute to the workings of the body. The lab pursues "dynamic structure-based drug discovery," which actively applies the motions of proteins and RNA to drug discovery. The lab also develops new NMR methods, such as measurements of high-molecular-weight proteins and analyses inside living cells.
Masanobu Uchiyama, Professor
Chemistry & Catalysis1 student voices
The Fundamental Organic Chemistry Lab studies the properties and phenomena of matter, seeking to understand them through the "language of chemistry": molecules, atoms, and electrons. The lab develops reactions that freely control the bonds between atoms, with the aim of creating functional materials. The lab develops techniques to precisely design and synthesize molecules as small as one billionth of a meter (a nanometer) or less. Built on three pillars (synthetic organic chemistry, spectroscopy and physical chemistry, and theoretical chemistry and computational science), the lab pursues chemistry that crosses disciplinary boundaries.
Motomu Kanai, Professor
Chemistry & Catalysis1 student voices
The lab studies synthetic organic chemistry, in which molecules are designed and made, with new catalytic reactions at its core. Research proceeds in three areas: creating molecules, creating functions, and creating order. The lab also works on drug discovery based on a new concept: having chemical catalysts act inside the body to treat disease. Aiming for substantial, long-term research that looks 10 to 20 years ahead, the lab provides a place where students can experience the excitement of cutting-edge research.
Yuko Otani, Associate Professor
Chemistry & Catalysis1 student voices
The Medicinal Chemistry Lab discovers new phenomena in organic chemistry, tests how general they are, and uses them to create functional organic molecules. Its goal is to build an integrated form of organic chemistry in which the chemical phenomena the lab has discovered are applied to the creation of biologically active molecules. The lab is interested not only in synthesizing highly active compounds but also in understanding, at the level of protein structural chemistry, how their activity arises from their structure. By exploring the new organic chemistry and new functions that novel molecular structures generate, the lab pursues new concepts that are broadly applicable.
Yukiko Gotoh, Professor
Bio & Life Sciences0 student voices
The lab studies at the molecular level how cell fate is determined, focusing on the process by which the brain is formed. Neural stem cells in the brain proliferate while generating many types of neurons and glial cells, and these cells assemble the brain as a tissue. Focusing on the regulation of gene expression by the epigenome and by chromatin inside the nucleus, the lab investigates the mechanisms that control the fates of neural stem cells and neurons. The lab is also working to understand how abnormalities in brain development lead to conditions such as psychiatric disorders.
Yuichi Taniguchi, Professor
Bio & Life Sciences0 student voices
The Bioanalytical Chemistry Lab studies new analytical methods that capture how life works at the molecular level. By combining insights from biology, chemistry, physics, AI, and other fields, the lab captures biological phenomena that earlier methods could not reveal. The lab investigates at the molecular level why drugs work or fail to work, and the mechanisms behind how each cell responds differently to a drug. It aims to apply these results to AI-based prediction of drug response, laying the foundation for next-generation drug discovery and precision medicine.
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